Results 81 to 90 of about 67,215 (309)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Resilience and well-being among children of migrant parents in South-East Asia

, 2012
There has been little systematic empirical research on the well-being of children in transnational households in South-East Asia—a major sending region for contract migrants.
Graham, Elspeth, Jordan, LP, Jordan, Lucy, Elspeth Graham, Graham, E, Lucy P. Jordan   +5 more
core   +1 more source

Looking at the gaps and program needs to address the impact on children of agricultural workers in Puerto Rico during and after public health emergencies

Frontiers in Public Health, 2022
Marysel Pagán-Santana, Amy K. Liebman, Aníbal Y. López-Correa   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Co‐designing a theory‐informed, multicomponent intervention to increase vaccine uptake with Congolese migrants: A qualitative, community‐based participatory research study (LISOLO MALAMU)

Health Expectations
Introduction Disparities in the uptake of routine and COVID‐19 vaccinations have been observed in migrant populations, and attributed to issues of mistrust, access and low vaccine confidence.
Alison F. Crawshaw, Lusau M. Kitoko, Sarah L. Nkembi, Laura M. Lutumba, Caroline Hickey, Anna Deal, Jessica Carter, Felicity Knights, Tushna Vandrevala, Alice S. Forster, Sally Hargreaves   +10 more
doaj   +1 more source

Infrastructural familiarity: How Russian-speaking migrants are expected to become active participants in navigating UK vaccination programmes

SSM: Qualitative Research in Health
International migrants remain an under-immunised group globally. Understanding expectations that national public health infrastructures pose upon newly arrived migrants is crucial for unpacking the challenges that migrants face when seeking vaccination ...
A. Kamenshchikova, A. Deal, J. Carter, F. Knights, O. Bouaddi, N. Aspray, S. Bojang, F. Seedat, N. Sanchez-Clemente, A. Jachmann, S. Hargreaves   +10 more
doaj   +1 more source

Migrant Health: a value for Public Health

, 2012
The health matters associated with migration are crucial public health challenges faced by both governments and societies. According to United Nations estimates, 120 million of the approximately 175 million migrants worldwide are migrant workers with their families.
Laurenti, Patrizia, Bruno, Stefania
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Determinants of internal migrant health and the healthy migrant effect in South India: a mixed methods study

BMC International Health and Human Rights, 2017
Background Internal labour migration is an important and necessary livelihood strategy for millions of individuals and households in India. However, the precarious position of migrant workers within Indian society may have consequences for the health of ...
Warren Dodd, Sally Humphries, Kirit Patel, Shannon Majowicz, Matthew Little, Cate Dewey   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source