Results 71 to 80 of about 557,024 (390)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
, 2019 espanolEl presente articulo analiza la superposicion del discurso politico del actual gobierno de Presidente Pinera (2018-2022) y el discurso de los medios de comunicacion respecto de la migracion y de los migrantes.
Carolina Stefoni, S. Brito
semanticscholar +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Revista de la Universidad Industrial de Santander. Salud, 2019 Introducción: En el fenómeno migratorio desde Venezuela hacia Colombia, las mujeres representan una proporción significativa entre los migrantes irregulares; de ellas, las gestantes han sido priorizadas por sus condiciones particulares de vulnerabilidad.
J. F. Niño +7 more
semanticscholar +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
La violenza sulle donne immigrate in Europa [PDF]
, 2008 Este texto caracteriza a situação das mulhres migrantes na União Européia. Na Europa, em 2006, havia um contingente de 18.5 milhões de migrantes procedentes de países do Terceiro Mundo, 54% dos quais eram mulheres.
Martini Vial, Sandra Regina +1 more
core +5 more sources
Retirantes cearenses na província do Amazonas: colonização, trabalho e conflitos (1877-1879)
Revista Brasileira de História, 2015 RESUMO O artigo trata da migração de cearenses para a província do Amazonas em decorrência da grande seca que afetou o Ceará entre 1877 e 1879. Acompanhamos os esforços de rearticulação de colônias agrícolas, anteriormente planejadas para receber ...
Edson Holanda Lima Barboza
doaj +1 more source
Revista de Investigación en Psicología, 2023 La crisis en Venezuela ha llevado a un gran número de ciudadanos a emigrar a diferentes países, incluyendo Perú; sin embargo, esto ha traído consigo una serie de desafíos en términos de salud física y mental para los migrantes venezolanos.
Yashumi Raquel Huamani López +3 more
doaj +1 more source