Results 31 to 40 of about 70,611 (199)

Improving oral health in migrant and underserved populations: evaluation of an interactive, community-based oral health education program in Washington state

BMC Oral Health, 2019
Objectives Oral health is one of the greatest unmet health needs of migrant farmworkers and many migrant workers lack basic oral health knowledge. This paper presents evaluation results for an oral health education program designed to both increase ...
Ileana Ponce-Gonzalez, Allen Cheadle, Gino Aisenberg, Laura Flores Cantrell   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PTSD and complex PTSD manifestations in Sub-Saharan Africa: A systematic review of qualitative literature

SSM - Mental Health
Complex post-traumatic stress disorder (CPTSD) was introduced in the ICD-11 as a new diagnosis and was framed in accordance with WHO guidelines of clinical utility and cross-cultural applicability.
Marion Bovey, Nadine Hosny, Felicia Dutray, Eva Heim   +3 more
doaj   +1 more source

Entre Deux Drapeaux: Les ouvriers capverdiens au Portugal pendant la période revolutionnaire (1974-1976)

Cadernos de Estudos Africanos, 2011
Marqués par un climat de décolonisation, les mois qui suivirent la Révolution des Oeillets (25 avril 1974) constituèrent une période d’incertitude pour les Capverdiens vivant et travaillant en tant qu’ouvriers au Portugal.
Antoine Acker
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Trauma-related cultural concepts of distress: A systematic review of qualitative literature from the middle east and North Africa, and Sub-Saharan Africa

SSM - Mental Health
Culture shapes how individuals experience, understand, and express trauma-related distress. The study of cultural concepts of distress (CCDs) provides valuable insights into culturally specific symptoms, syndromes, and explanatory models that emerge in ...
Marion Bovey, Nadine Hosny, Felicia Dutray, Eva Heim   +3 more
doaj   +1 more source

Between crisis, agency and return: the vulnerability of Bolivian migrants in Italy [PDF]

Revista CIDOB d'Afers Internacionals, 2014
This article addresses the interrelationships between the economic crisis, international migration and the labour market, and their impact on female migration agency, both in the decision to migrate and in the subsequent possibility of return to Bolivia.
Isabel Yépez del Castillo, Mirko Marzadro   +1 more
doaj