Results 111 to 120 of about 3,438,934 (379)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Irregular migration in senegal faith, dreams and human smuggling through the desert and sea [PDF]

, 2020
The paper provides a bottom up view on human smuggling facilitation and the rationale behind extremely high-risk and complex irregular migration journeys from the Kolda region of Senegal across the Sahara and through the Atlantic sea.
Deshingkar, Priya, Gueye, Doudou
core  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The performance and yield of tuberculosis testing algorithms using microscopy, chest x-ray, and Xpert MTB/RIF

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2019
Setting: The introduction of Xpert MTB/RIF (Xpert) and renewed interest in chest x-ray (CXR) for tuberculosis testing has provided additional choices to the smear-based diagnostic algorithms used by TB programs previously.
Jacob Creswell, Zhi Zhen Qin, Rajendra Gurung, Bikash Lamichhane, Deepak Kumar Yadav, Mohan Kumar Prasai, Nirmala Bista, Lal Mani Adhikari, Bishwa Rai, Santat Sudrungrot   +9 more
doaj  

The Ethnology of Germany.-Part 3: The Migration of the Saxons. [PDF]

, 1878
Henry H. Howorth
openalex   +1 more source

A Techno-economic Analysis of Network Migration to Software-Defined Networking [PDF]

arXiv, 2013
As the Software Defined Networking (SDN) paradigm gains momentum, every network operator faces the obvious dilemma: when and how to migrate from existing IP routers to SDN compliant equipments. A single step complete overhaul of a fully functional network is impractical, while at the same time, the immediate benefits of SDN are obvious.
arxiv  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS [PDF]

, 1914
Mary R. Lawson
openalex   +1 more source

Commentary on session II: The politics of migration and trade [PDF]

Summary and discussion of the two papers in this session: "U.S.-Mexican migration cooperation: obstacles and opportunities" by Marc R. Rosenblum; "Political implications of U.S. public attitudes toward immigration on the immigration policymaking process"
Gary P. Freeman
core