By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
COVID-19, Migrants, Refugees, Mobile Workers: Global Assessment and Action Agenda
The COVID-19 pandemic has disproportionately affected millions of migrants, refugees, asylum-seekers, and stateless persons as well as IDPs worldwide. At the same time, the dependence of economies and societies on migrant and refugee labour to perform ...
Patrick Taran, Olga Kadysheva
doaj +1 more source
Forced labour and migration to the UK [PDF]
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Anderson, Bridget, Rogaly, Ben
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Measuring irregular migration in Chile: The use of data linkage methods
Foreign population in Chile almost doubled between 2017 and 2021. In recent years, the sources to measure the phenomenon has been the 2017 Census, plus administrative data from the migratory institutions.
Belén Harnecker, Felipe Mallea
doaj +1 more source
Planet migration: self-gravitating radiation hydrodynamical models of protoplanets with surfaces [PDF]
We calculate radial migration rates of protoplanets in laminar minimum mass solar nebula discs using three-dimensional self-gravitating radiation hydrodynamical (RHD) models.
Alexander +74 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Intensification of work-place regimes in British agriculture: the role of migrant workers [PDF]
In Britain, international migrants have very recently become the major workforce in labour-intensive agriculture. This paper explores the causes of the dramatic increase since the 1990s in the employment of migrant workers in this sub-sector.
Rogaly, Ben
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

