LPS differentially regulates adhesion and transendothelial migration of human monocytes under static and flow conditions [PDF]
One of the key components of the innate immune response is the recognition of microbial products such as LPS by Toll-like receptors on monocytes and neutrophils. We show here that short-term stimulation of primary human monocytes with LPS led to an increase in adhesion of monocytes to endothelial cells and a dramatic decrease in transendothelial ...
Bradfield, Paul F. +3 more
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Globalization of international migration: Social challenges and policy implication
In the second half of the XX century, the humankind witnessed the insurmountable and irreversible power of globalization processes, which influence all spheres of social life and establish a global system of interdependency between countries and nations.
I A Aleshkovski
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Priorities and tools of regulation of external migration in the Carpathian region of Ukraine
Purpose. The purpose of the article is to identify trends in external migration of the population in the Carpathian region of Ukraine and to develop applied recommendations for the regulation of external migration in the context of the need to save human
Sergiy Semiv +4 more
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CONNECTION OF MIGRATION FLOWS AND STATE SECURITY: INTERNATIONAL LEGAL REGULATION
The article is devoted to the consideration of the foundations and dynamics of international legal regulation of migration flows through the value legal analysis of the connection between threats to state security from transnational refugee flows. The Author begins with an analysis of the relationship between migration and security, which he proposes ...
Krystyna Zhevrovska +1 more
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Nuclear Movement Regulated by Cdc42, MRCK, Myosin, and Actin Flow Establishes MTOC Polarization in Migrating Cells [PDF]
The microtubule-organizing center (MTOC) is reoriented between the nucleus and the leading edge in many migrating cells and contributes to directional migration. Models suggest that the MTOC is moved to its position during reorientation. By direct imaging of wound-edge fibroblasts after triggering MTOC reorientation with soluble factors, we found ...
Gomes, Edgar R. +2 more
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Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling [PDF]
Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalies is not understood.
Yi Jin +7 more
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Gli interventi nazionali sui problemi della migrazione: strategie e programmi (National interventions on the issues of migration: strategies and programs) [PDF]
Europe has become the first continent of attraction for migrants and is also the first continent as for incidence of the population emigrated to the total of population.
Carmine CLEMENTE, Raffaella PATIMO
doaj
Migration Management in the Western Balkan Region: The Case of Bosnia and Herzegovina
Introduction. For centuries, the Western Balkan region has been actively involved in international migration processes, mainly generating flows of migrants to other states.
Stanislav A. Gorokhov +2 more
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Modelling Internal Migration with the Use of System Dynamics
The article provides a detailed analysis of the theoretical basis for the study of labor migration, investigates the preconditions for interregional migration in Ukraine, identifies the effects of expulsion and attraction in different regions, and ...
Alina Novik
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Each Step during Transendothelial Migration of Flowing Neutrophils is Regulated by the Stimulatory Concentration of Tumour Necrosis Factor-α [PDF]
Migration of circulating neutrophils occurs in several steps: capture and rolling adhesion are followed by activation of beta 2-integrins and immobilisation, and then neutrophils move over and through the endothelium. However, it is not clear how the underlying mechanisms and completion of each step depend on the concentration of stimulatory cytokines ...
P, Bahra +4 more
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