Results 31 to 40 of about 17,026 (178)

New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Elgueta I, Lewis D, Morgan ER, Helm J.
europepmc   +2 more sources

Factors influencing feline antiparasitic prescriptions by veterinarians and demographics across parts of the UK. [PDF]

Vet Rec Open
Abstract Background Antiparasitic drugs used in companion animals may persist in the environment, contributing to ecological contamination and raising One Health concerns. Understanding behavioural patterns of veterinarians’ prescription is essential for development of effective antiparasitic stewardship programmes. Methods A survey of 29 questions was
Hobbs RE, Duszak-Kowal A.
europepmc   +2 more sources

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Ancylostoma caninum is the most prevalent intestinal nematode of dogs, and has a zoonotic potential. Multiple-drug resistance (MDR) has been confirmed in a number of A.
Pablo D. Jimenez Castro, Abdelmoneim Mansour, Samuel Charles, Joe Hostetler, Terry Settje, Daniel Kulke, Ray M. Kaplan   +6 more
doaj   +1 more source

An LC-MS Method for Determination of Milbemycin Oxime in Dog Plasma [PDF]

Journal of Chromatographic Science, 2013
An HPLC-MS method has been developed and validated for the quantitative determination of milbemycin oxime (MBO) in dog plasma. The developed method has been then applied in in vivo clinical studies to obtain pharmacokinetics of MBO in blood after its oral administration. Samples were extracted using solid-phase extraction (SPE).
Qianqian, Xu, Jichang, Li, Zhiqiang, Shen, Shijin, Guo, Yubo, Wang, Feng, Li   +5 more
openaire   +2 more sources

Efficacy of a chewable tablet containing sarolaner, moxidectin, and pyrantel (Simparica Trio®) in the treatment of sarcoptic mange caused by Sarcoptes scabiei mite infestations in dogs

Parasites & Vectors, 2023
Background Infestation with Sarcoptes scabiei in dogs is a debilitating disease if left untreated and is transmissible to humans. Two field studies were conducted to confirm the efficacy of orally administered sarolaner in combination with moxidectin and
Csilla Becskei, Julian Liebenberg, Tiago Fernandes, Stasia Borowski, Lina D’Hanis, Sean P. Mahabir   +5 more
doaj   +1 more source

Anthelmintic Resistance in Ancylostoma caninum: A Comprehensive Review. [PDF]

Vet Med Sci
This review summarizes the emergence of anthelmintic resistance in Ancylostoma caninum, with a focus on drug classes affected, global prevalence and resistance mechanisms. Early detection and integrated control strategies are essential to combat its spread.
Sönmez Hİ, Madak E, Karaer MC, Sarımehmetoğlu HO.   +3 more
europepmc   +2 more sources

Milbemycin A4 oxime as a probe of azole transport in Candida glabrata [PDF]

FEMS Yeast Research, 2014
Azole resistance in Candida glabrata, a pathogenic yeast, has prompted studies of compounds that have therapeutic potential by reversing azole resistance. Milbemycin A4 oxime blocked azole efflux and enhanced azole susceptibility fourfold in 28 clinical isolates of C. glabrata.
Bryan, Walker, Koichi, Izumikawa, Huie-Fung, Tsai, John E, Bennett   +3 more
openaire   +2 more sources

Examination of the “susceptibility gap” in the treatment of canine heartworm infection

Parasites & Vectors, 2017
Background The “susceptibility gap” in a dog diagnosed with adult heartworms has been defined as the period of time in which some Dirofilaria immitis stages are not susceptible to treatment with either macrocyclic lactones or melarsomine dihydrochloride.
Dwight D. Bowman, Jason Drake
doaj   +1 more source

Effects of Oral Macrocyclic Lactone Heartworm Preventatives on Retinal Function and Chromatic Pupillary Light Reflex in Healthy Companion Dogs. [PDF]

Vet Ophthalmol
ABSTRACT Objective Determine the effect of oral macrocyclic lactone heartworm‐preventative medications on retinal function and chromatic pupillary light reflex (cPLR) in healthy dogs. Animals Studied Cross‐sectional retrospective: 60 dogs (n = 33 females) with heartworm medication administration status and electroretinogram (ERG) data available ...
Hopper RG, Ludwig AL, Salzman MM, Elazegui E, Rogers CM, Bentley E, Mowat FM.   +6 more
europepmc   +2 more sources