Results 91 to 100 of about 2,335,709 (315)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Brain SciencesBackground: There is currently increasing interest in the implication of traumatic brain injury (TBI) as a potential risk factor for long-term neurodegenerative conditions, such as dementia and Alzheimer’s disease (AD).
Ioannis Mavroudis +5 more
doaj +1 more source
Treatment of mild chronic obstructive pulmonary disease [PDF]
, 2008 Alex Chee, Don D SinDepartment of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul’s Hospital ...
Don D Sin, Alex Chee
core
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
New Perspectives in the Management of Mild to Moderate Asthma in Children
Journal of Asthma and Allergy, 2021 Hacer Ilbilge Ertoy Karagol, Arzu Bakirtas Department of Pediatric Allergy and Asthma, Gazi University School of Medicine, Ankara, TurkeyCorrespondence: Hacer Ilbilge Ertoy KaragolDepartment of Pediatric Allergy and Asthma, Gazi University School of ...
Ertoy Karagol HI, Bakirtas A
doaj
Living with stigma and the self-perceptions of people with mild intellectual disabilities [PDF]
, 2010 There is now overwhelming evidence concerning the awareness people with moderate to mild intellectual disabilities' have about the stigma they experience in their lives.
Kirsten Stalker +8 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Mild hyperphenylalaninemia: to treat or not to treat [PDF]
Journal of Inherited Metabolic Disease, 2011 AbstractOne of the issues to be resolved in phenylketonuria is whether patients with mild hyperphenylalaninemia need treatment, or in other words, in what patients treatment needs to be started. Do patients need treatment when phenylalanine concentrations in blood are >360 μmol/L or >600 μmol/L? This paper reviews the literature on the outcome of
openaire +2 more sources
Management of gestational hypertension and mild pre-eclampsia at term [PDF]
, 2011 Zwangerschapshypertensie en preëclampsie compliceren 6-8% van alle zwangerschappen en vormen in Nederland de belangrijkste oorzaak van maternale morbiditeit en mortaliteit. Vaak is het ziektebeeld mild en treedt op in de aterme periode.
Koopmans, Corine M +2 more
core
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source