Results 111 to 120 of about 2,335,709 (315)

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease [PDF]

, 2010
The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail.
Bartley, Máiréad, Lamberton, Franck, O'Neill, Des, D Rónán Collins, David Prvulovic, O'Dwyer, Laurence, D. Rónán Collins, Collins, D Rónán, Máiréad Bartley, Faluyi, Yetunde O., Harald Hampel, Bokde, Arun L. W., Mazoyer, Bernard M., Mazoyer, Bernard, Yetunde O. Faluyi, Hampel, Harald, Bokde, Arun L W, Laurence O'Dwyer, Arun L. W. Bokde, Prvulovic, David, Michael Ewers, Ewers, Michael, Faluyi, Yetunde O, Colby Tanner, Tanner, Colby, Franck Lamberton, Collins, D. Rónán, Coughlan, Tara, Des O'Neill, Arun L W Bokde, Yetunde O Faluyi, Bernard Mazoyer, Tara Coughlan   +32 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Challenges of achieving sustainable community health services for community case management of malaria

BMC Public Health, 2018
Background Community Case Management of malaria (CCMm) using Community Health Workers (CHWs) is an approach to improve access to timely and effective malaria case management in malaria endemic countries.
Michelle D. S. Boakye, Collins J. Owek, Elizabeth Oluoch, Juddy Wachira, Yaw A. Afrane   +4 more
doaj   +1 more source

Classification and management of mild head trauma [PDF]

, 2011
Almir F Andrade, Wellingson S Paiva, Matheus S Soares, Robson LO De Amorim, Wagner M Tavares, Manoel J TeixeiraDivision of Neurosurgery, Hospital Das Clínicas University of Sao Paulo Medical School, Sao Paulo, BrazilAbstract: Mild head trauma ...
Wellingson S Paiva, Matheus S Soares, Almir F Andrade, et al   +3 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Mild-to-moderate gestational iodine deficiency processing disorder [PDF]

, 2019
This synopsis paper aims to identify if a common pattern of learning and social difficulties can be conceptualized across recent longitudinal studies investigating the influence of mild-to-moderate gestational iodine deficiency (GID) on offspring’s ...
Kristen Hynes (14739886), John Burgess (14732812), Ian Hay (14738767)   +2 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Thermoregulatory management for mild therapeutic hypothermia [PDF]

, 2008
In recent years the use of mild therapeutic hypothermia as a means of neuroprotection has become an important concept for treatment after cerebral ischemic hypoxic injury.
Kimberger, Oliver, Kurz, Andrea
core  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Tumour risk associated with use of cellular telephones or cordless desktop telephones

World Journal of Surgical Oncology, 2006
Background The use of cellular and cordless telephones has increased dramatically during the last decade. There is concern of health problems such as malignant diseases due to microwave exposure during the use of these devices.
Söderqvist Fredrik, Carlberg Michael, Mild Kjell, Hardell Lennart   +3 more
doaj   +1 more source