Results 41 to 50 of about 2,335,709 (315)

Unveiling the complexities of mild stroke: an interpretative phenomenological analysis of the mild stroke experience [PDF]

, 2019
Introduction: Limited research has been conducted from a longitudinal and qualitative perspective on the experience of life after mild stroke. This restricts the knowledge held in this area.
Gustafsson, Louise, Tenelle Hodson, Cornwell, Petrea, Louise Gustafsson, Hodson, Tenelle, Petrea Cornwell   +5 more
core   +1 more source

Reversion of Gut Microbiota during the Recovery Phase in Patients with Asymptomatic or Mild COVID-19: Longitudinal Study

Microorganisms, 2021
Patients with COVID-19 have been reported to experience gastrointestinal symptoms as well as respiratory symptoms, but the effects of COVID-19 on the gut microbiota are poorly understood.
Han-Na Kim, Eun-Jeong Joo, Chil-Woo Lee, Kwang-Sung Ahn, Hyung-Lae Kim, Dong-Il Park, Soo-Kyung Park   +6 more
doaj   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Cortical sources of resting state EEG rhythms are sensitive to the progression of early stage Alzheimer's disease [PDF]

, 2013
Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with Alzheimer's disease (AD). Here we tested the hypothesis that these sources are also sensitive to the progression of early stage AD over the course of ...
Nicola Marzano, Lizio, Roberta, Montella, Patrizia, F. Nobili, Giovanni B Frisoni, Vernieri, Fabrizio, De Salvo S, NOBILI, FLAVIO MARIANO, G. Tedeschi, Vernieri F, Nobili, Flavio, S. De Salvo, Frisoni GB, J. C. Richardson, De Salvo, Simona, P. M. Rossini, F. Vernieri, Babiloni C, Salvatore E, G. Rodriguez, Frisoni, Giovanni B., Paolo M. Rossini, A. Soricelli, Guido Rodriguez, Jill C. Richardson, G. B. Frisoni, Fabrizio Vernieri, C. Del Percio, Mundi C, Babiloni, Claudio, Salvatore, Elena, S. Marino, Del Percio C, Rossini P.M., Soricelli, Andrea, Marzano N, E. Salvatore, Elena Salvatore, Rossini, Paolo Maria, Lizio R, F. Ursini, Mundi, Ciro, Roberta Lizio, Silvia Marino, Tedeschi, Gioacchino, Richardson, Jill C., Montella P, R. Ferri, Flavio Nobili, Rodriguez G, Rossini PM, C. Mundi, Francesca Ursini, Filomena I.I. Cosentino, Gioacchino Tedeschi, Soricelli A, Tedeschi G, Raffaele Ferri, Cosentino, Filomena I. I., Ferri R, Richardson JC, F. I. I. Cosentino, Patrizia Montella, Marzano, Nicola, Del Percio, Claudio, Marino S, Claudio Del Percio, Rossini, Paolo M., Andrea Soricelli, P. Montella, Ferri, Raffaele, Marino, Silvia, Ursini, Francesca, Nobili F, N. Marzano, Cosentino, Filomena I.I., Rodriguez, Guido, Ursini F, Claudio Babiloni, Cosentino FI, Simona De Salvo, Ciro Mundi, Frisoni, Giovanni B   +82 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial

Trials, 2021
Objectives The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.
Naoki Hosogaya, Taiga Miyazaki, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Tomoya Kurokawa, Yohei Kawasaki, Michiko Hanawa, Yasuhisa Fujii, Hideki Hanaoka, Shingo Iwami, Koichi Watashi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Takaji Wakita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae, Shigeru Kohno, Nelfinavir Study Group   +21 more
doaj   +1 more source

Significant National Declines in Neurosurgical Intervention for Mild Traumatic Brain Injury with Intracranial Hemorrhage: A 13-Year Review of the National Trauma Data Bank

Neurotrauma Reports, 2023
There have been large changes over the past several decades to patient demographics in those presenting with mild traumatic brain injury (mTBI) with intracranial hemorrhage (ICH; complicated mTBI) with the potential to affect the use of neurosurgical ...
Alessandro Orlando, Josef Coresh, Matthew M. Carrick, Glenda Quan, Gina M. Berg, Laxmi Dhakal, David Hamilton, Robert Madayag, Carlos H. Palacio Lascano, David Bar-Or   +9 more
doaj   +1 more source

Social Competence and Executive Functioning in Adolescents Following a Mild Traumatic Brain Injury [PDF]

, 2014
A traumatic brain injury (TBI) is one of the most common injuries sustained by adolescents and a leading cause of death and long-term disability. The vast majority of these cases are mild and yet they can cause a range of difficulties across multiple ...
Hollands, David Michael
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration. [PDF]

, 2013
OBJECTIVE: To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).
Manning, Emily N, Manning, EN, Leung, Kelvin K, Leung, Kelvin K., Bartlett, Jonathan W., Fox, Nick C, Fox, Nick C., Barnes, Josephine, Ourselin, Sebastien, Alzheimer's Disease Neuroimaging Initiative, Bartlett, Jonathan W, Bartlett, JW, Ourselin, S, Fox, NC, Manning, Emily N., Barnes, J, Leung, KK   +16 more
core   +1 more source