Results 61 to 70 of about 2,335,709 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mild traumatic brain injury during infancy: Executive function and behavioural outcomes 24 months post-injury [PDF]

, 2014
Traumatic brain injury (TBI) is a leading cause of death and disability for children and young people worldwide. Research has found that children in infancy and early childhood are at the highest risk of sustaining a TBI; and that mild TBI accounts for a
Zareie, Setareh
core  

Tribological behavior of mild steel under canola biolubricant conditions [PDF]

, 2021
New lubricants based on vegetable oil were developed in this study. Different blends of canola oil mixed with fully synthetic two stock engine oils were developed (0, 20%, 40%, 60%, and 80% of synthetic oil).
Shalwan, A., Yousif, B. F., Alajmi, M., Alajmi, F. H.   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Misperceptions about “light” cigarettes among smokers in Zambia: Findings from the International Tobacco Control (ITC) Zambia Survey

Tobacco Prevention and Cessation, 2016
Introduction Little is known about beliefs about “light” cigarettes (“lights”) in African countries where both tobacco industry activity and tobacco control efforts are intensifying. This study in Zambia is the first to examine the prevalence and beliefs
Susan C Kaai, Geoffrey T Fong, Annika C Green, Fastone Goma, Gang Meng, Anne CK Quah, Ron Borland, Masauso M Phiri, Tara Elton-Marshall   +8 more
doaj   +1 more source

Review of the risks and/or benefits of thyroxine treatment in ‘mild’ subclinical hypothyroidism [PDF]

, 2013
Subclinical hypothyroidism (SCH) is a form of mild thyroid failure and is a commonly encountered condition in clinical practice. It denotes the presence of a raised serum thyroid stimulating hormone (TSH) and normal serum free thyroid hormone ...
Agius, Rachel
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The EU Directive on Electromagnetic Fields—Practical Experience of Field Measurements

Applied Sciences
The EU directive on exposure to electromagnetic fields was published in 2004, but due to some problems it was not introduced in the EU countries before 2016.
Kjell Hansson Mild
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment [PDF]

Journal of Alzheimer’s Disease, 2018
Background: Neuropsychiatric symptoms (NPS) are non-cognitive, behavioral, or psychiatric symptoms, common in mild cognitive impairment (MCI) and associated with a higher risk of dementia. Mild behavioral impairment (MBI) is a validated diagnostic entity, that describes the emergence of later life NPS in pre ...
Mallo López, Sabela Carme, Ismail, Zahinoor, Pereiro Rozas, Arturo X., Facal Mayo, David, Lojo Seoane, Cristina, Campos Magdaleno, María, Juncos Rabadán, Onésimo   +6 more
openaire   +3 more sources