Results 121 to 130 of about 482,563 (349)

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Tau and atrophy: domain-specific relationships with cognition. [PDF]

, 2019
BackgroundLate-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains.
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Dale, Anders M, Digma, Leonardino A, Madsen, John R, Reas, Emilie T   +6 more
core  

Network Structure of Depressive Symptomatology in Elderly with Cognitive Impairment

Medicina
Objective and objectives: Patients with cognitive disorders such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI) frequently exhibit depressive symptoms. Depressive symptoms can be evaluated with various measures and questionnaires.
Jeehyung Pyo, Hyukjun Lee, Jakyung Lee, Daseul Lee, Hyeona Yu, Shinn-Won Lim, Woojae Myung, Doh-Kwan Kim   +7 more
doaj   +1 more source

Mild Cognitive Impairment in the Population and Physical Health: Data on 1,435 Individuals Aged 75 to 95 [PDF]

, 2000
Giovanni B. Frisoni, Laura Fratiglioni, Johan Fastbom, Zhenyu Guo, Matti Viitanen, Bengt Winblad   +5 more
openalex   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Bibliometric analysis of papers on mild cognitive impairment nursing in China

International Journal of Nursing Sciences, 2017
Purpose: To supply further references by analyzing the status of research on mild cognitive impairment nursing in China. Methods: Papers on mild cognitive impairment nursing published between 2005 and 2014 were collected from China National Knowledge ...
Yating Ai, Kaili Sun, Hui Hu
doaj  

Associating transportation planning-related measures with Mild Cognitive Impairment [PDF]

arXiv
Understanding the relationship between mild cognitive impairment and driving behavior is essential to improve road safety, especially among older adults. In this study, we computed certain variables that reflect daily driving habits, such as trips to specific locations (e.g., home, work, medical, social, and errands) of older drivers in Nebraska using ...
arxiv  

Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review) [RETIRED] [PDF]

, 2001
Ronald C. Petersen, J E Stevens, Mary Ganguli, Eric G. Tangalos, Jeffrey L. Cummings, Steven T. DeKosky   +5 more
openalex   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source