Results 131 to 140 of about 249,115 (256)

Emotional-cognitive integration in aging: the role of alexithymia in mild cognitive impairment. [PDF]

Front Public Health
Marselli G, Corbo I, Pecchinenda A, Forte G, Favieri F, Troisi G, Blasutto B, Casagrande M.   +7 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Mild cognitive impairment: why bother?

Annals of General Psychiatry, 2008
Gold Gabriel
doaj   +1 more source

Metabolic profile association with white matter hyperintensity in patients with mild cognitive impairment. [PDF]

IBRO Neurosci Rep
Ariaei A, Zamiri R, Ghasemi A, Rezayani B, Rezayani S, Ezatpour A, Farshidi N, Sheikhi EA, Roghanian A, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer's Disease Metabolomics Consortium.   +10 more
europepmc   +1 more source

Mild cognitive impairment and subjective cognitive impairment [PDF]

Psychogeriatrics, 2008
Masatoshi TAKEDA, Takashi MORIHARA, Masayasu OKOCHI, Golam SADIK, Toshihisa TANAKA   +4 more
openaire   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Database of Speech and Language Affected by Mild Cognitive Impairment. [PDF]

Sci Data
Rusko M, Brandoburová P, Kevická V, Trnka M, Sabo R, Darjaa S, Malschitz R.   +6 more
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Scalable CT-based prognostic modeling of dementia conversion in mild cognitive impairment. [PDF]

Sci Rep
Park S, Ahn J, Na DL, Kim HJ, Jang H, Kim JP, Kang SH, Yun J, Chun MY, Seo SW, Kwak K.   +10 more
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source