Results 91 to 100 of about 211,459 (306)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Mild Solutions of Fractional Integrodifferential Diffusion Equations with Nonlocal Initial Conditions via the Resolvent Family

, 2023
Fractional integrodifferential diffusion equations play a significant role in describing anomalous diffusion phenomena. In this paper, we study the existence and uniqueness of mild solutions to these equations.
Zhiyuan Yuan, Jia Mu, Yong Zhou
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Existence Results of Mild Solutions for Impulsive Fractional Evolution Equations with Periodic Boundary Condition

, 2017
This paper discusses the existence of mild solutions for a class of fractional impulsive evolution equation with periodic boundary condition and noncompact semigroup.
Baolin Li, Haide Gou
core   +1 more source

Optimal Solutions for a Class of Impulsive Differential Problems with Feedback Controls and Volterra-Type Distributed Delay: A Topological Approach

Mathematics
In this paper, the existence of optimal solutions for problems governed by differential equations involving feedback controls is established for when the problem must account for a Volterra-type distributed delay and is subject to the action of impulsive
Paola Rubbioni
doaj   +1 more source

Some approximation results for mild solutions of stochastic fractional order evolution equations driven by Gaussian noise. [PDF]

Stoch Partial Differ Equ, 2023
Fahim K, Hausenblas E, Kovács M.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Nonlocal Conformable Differential Inclusions Generated by Semigroups of Linear Bounded Operators or by Sectorial Operators with Impulses in Banach Spaces

Axioms
This paper aims to explore sufficient conditions for the existence of mild solutions to two types of nonlocal, non-instantaneous, impulsive semilinear differential inclusions involving a conformable fractional derivative, where the linear part is the ...
Faryal Abdullah Al-Adsani, Ahmed Gamal Ibrahim   +1 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source