Results 81 to 90 of about 644,438 (285)

Multivariate Spectral Estimation based on the concept of Optimal Prediction

, 2014
In this technical note, we deal with a spectrum approximation problem arising in THREE-like multivariate spectral estimation approaches. The solution to the problem minimizes a suitable divergence index with respect to an a priori spectral density.
Zorzi, Mattia
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mild Solution of Semilinear SPDEs with Young Drifts

, 2023
17 ...
Liang, Jiahao, Tang, Shanjian
openaire   +2 more sources

Existence of mild solutions for fractional evolution equations [PDF]

Journal of Integral Equations and Applications, 2013
The authors study on abstract spaces the existence of mild solutions for a nonlocal Cauchy-type problems of certain fractional evolution equations involving the Riemann-Liouville derivative. The problems solved by the authors is not trivial, they use to obtain the main results the theory of Hausdorff measure of non-compactness.
Zhou, Yong, Zhang, Lu, Shen, Xiao Hui
openaire   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Existence and uniqueness of positive mild solutions for a class of fractional evolution equations on infinite interval

Boundary Value Problems, 2017
Based on an equivalent integral equation of a new type for a class of fractional evolution equations, which is different from those obtained in the existing literature, the paper investigates a class of fractional evolution equations with nonlocal ...
Yi Chen, Zhanmei Lv, Liang Zhang
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Almost Periodicity of Mild Solutions of Inhomogeneous Periodic Cauchy Problems

Journal of Differential Equations, 1999
The authors consider a mild solution \(u\) to the well-posed inhomogeneous Cauchy problem \[ u'(t)= A(t)u(t)+ f(t), \] on a Banach space \(X\), where \(A(\cdot)\) is periodic. For a problem on \(\mathbb{R}_+\) the authors show that \(u\) is asymptotically almost-periodic if \(f\) is asymptotically almost-periodic, \(u\) is bounded, uniformly continuous
Batty, C, Hutter, W, Rabiger, F
openaire   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source