Results 81 to 90 of about 211,459 (306)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Existence of anti-periodic mild solutions for semilinear evolution equations

, 2011
In this paper we study the existence of anti-periodic mild solutions for a class of semilinear evolution equations in Banach spaces and extend some related results in this direction.
Qing Liu, Liu, Qing
core   +1 more source

Mild Solutions for the Time-Fractional Navier-Stokes Equations with MHD Effects

, 2023
Recently, various techniques and methods have been employed by mathematicians to solve specific types of fractional differential equations (FDEs) with symmetric properties. The study focuses on Navier-Stokes equations (NSEs) that involve MHD effects with
Kinda Abuasbeh, Ramsha Shafqat, Azmat Ullah Khan Niazi, Muath Awadalla   +3 more
core   +1 more source

Local Existence and Regularity of Mild Solutions for Hadamard Fractional Semilinear Integro-Differential Equations with Compact Semigroups

Axioms
We investigate the local well-posedness of semilinear fractional integro-differential equations in Banach spaces with the Hadamard fractional derivative.
Ahmad Al-Omari, Mohammad H. M. Rashid
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ageing of polysulfone membranes in contact with bleach solution: Role of radical oxidation and of some dissolved metal ions [PDF]

, 2008
In water production plants using membrane processes, contact with chemicals such as chlorine plays an important role in membrane ageing. This experimental study was aimed at gaining a better understanding of the effect of hypochlorite cleaning solutions ...
Causserand, Christel, Lafaille, Jean-Pierre, Aimar, Pierre, Rouaix, Sandrine   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Machine learning solutions for maintenance of power plants [PDF]

, 2018
The primary goal of this work is to present analysis of current market for predictive maintenance software solutions applicable to a generic coal/gas-fired thermal power plant, as well as to present a brief discussion on the related developments of the ...
Kalabin, Stanislav
core  

Existence and uniqueness of positive mild solutions for a class of fractional evolution equations on infinite interval

Boundary Value Problems, 2017
Based on an equivalent integral equation of a new type for a class of fractional evolution equations, which is different from those obtained in the existing literature, the paper investigates a class of fractional evolution equations with nonlocal ...
Yi Chen, Zhanmei Lv, Liang Zhang
doaj   +1 more source