Results 71 to 80 of about 3,751,517 (253)

On the existence of mild solutions for neutral functional differential inclusions in Banach space [PDF]

open access: yes, 2007
A theorem on existence of mild solutions for partial neutral functional differential inclusions with unbounded linear part generating a noncompact semigroup in Banach space is ...
Guedda L.   +2 more
core   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Local Existence and Regularity of Mild Solutions for Hadamard Fractional Semilinear Integro-Differential Equations with Compact Semigroups

open access: yesAxioms
We investigate the local well-posedness of semilinear fractional integro-differential equations in Banach spaces with the Hadamard fractional derivative.
Ahmad Al-Omari, Mohammad H. M. Rashid
doaj   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

open access: yes, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S.   +12 more
core  

Asymptotically almost periodic mild solutions for some partial integrodifferential inclusions using scale of Banach spaces

open access: yes, 2023
We are interested in the existence of mild solutions for a class of partial integrodifferential inclusions in infinite dimensional Banach spaces. First, we show the existence of mild solutions with the help of a scale of Banach spaces, the theory of ...
El Matloub Jaouad, Ezzinbi Khalil
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Existence and uniqueness of positive mild solutions for a class of fractional evolution equations on infinite interval

open access: yesBoundary Value Problems, 2017
Based on an equivalent integral equation of a new type for a class of fractional evolution equations, which is different from those obtained in the existing literature, the paper investigates a class of fractional evolution equations with nonlocal ...
Yi Chen, Zhanmei Lv, Liang Zhang
doaj   +1 more source

On the mild solutions of higher‐order differential equations in Banach spaces [PDF]

open access: yes
For the higher-order abstract differential equation u(n)(t)=Au(t)+f(t), t∈ℝ, we give a new definition of mild solutions. We then characterize the regular admissibility of a translation-invariant subspace ℳ of BUC(ℝ,E) with respect to the above-mentioned
Nguyen Thanh Lan
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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