Results 71 to 80 of about 204,887 (266)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Optimal Solutions for a Class of Impulsive Differential Problems with Feedback Controls and Volterra-Type Distributed Delay: A Topological Approach

Mathematics
In this paper, the existence of optimal solutions for problems governed by differential equations involving feedback controls is established for when the problem must account for a Volterra-type distributed delay and is subject to the action of impulsive
Paola Rubbioni
doaj   +1 more source

Some approximation results for mild solutions of stochastic fractional order evolution equations driven by Gaussian noise. [PDF]

Stoch Partial Differ Equ, 2023
Fahim K, Hausenblas E, Kovács M.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Nonlocal Conformable Differential Inclusions Generated by Semigroups of Linear Bounded Operators or by Sectorial Operators with Impulses in Banach Spaces

Axioms
This paper aims to explore sufficient conditions for the existence of mild solutions to two types of nonlocal, non-instantaneous, impulsive semilinear differential inclusions involving a conformable fractional derivative, where the linear part is the ...
Faryal Abdullah Al-Adsani, Ahmed Gamal Ibrahim   +1 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Existence Results for Semilinear Differential Evolution Equations with Impulses and Delay

Cubo, 2010
In this paper, we establish sufficient conditions for the existence of mild and extremal solutions for some densely defined impulsive functional differential equations in separable Banach spaces with local and nonlocal conditions.
Nadjet Abada, Mouffak Benchohra, Hadda Hammouche   +2 more
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

On the regularity of mild solutions to complete higher order differential equations on Banach spaces [PDF]

Surveys in Mathematics and its Applications, 2015
For the complete higher order differential equation u(n)(t)=Σk=0n-1Aku(k)(t)+f(t), t∈ R (*) on a Banach space E, we give a new definition of mild solutions of (*). We then characterize the regular admissibility of a translation invariant subspace al M of
Nezam Iraniparast, Lan Nguyen
doaj