Results 51 to 60 of about 204,887 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Results on nonlocal stochastic integro-differential equations driven by a fractional Brownian motion

open access: yesOpen Mathematics, 2020
This paper deals with the existence of mild solutions for a class of non-local stochastic integro-differential equations driven by a fractional Brownian motion with Hurst parameter H∈12,1H\in \left(\tfrac{1}{2},1\right).
Issaka Louk-Man   +2 more
doaj   +1 more source

S-Almost Automorphic Solutions for Impulsive Evolution Equations on Time Scales in Shift Operators

open access: yesMathematics, 2020
In this paper, based on the concept of complete-closed time scales attached with shift direction under non-translational shifts (or S-CCTS for short), as a first attempt, we develop the concepts of S-equipotentially almost automorphic sequences ...
Chao Wang   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Existence of mild solutions for nonlocal perturbed evolution equations with infinite state-dependent delay in Fréchet spaces [PDF]

open access: yesArchives of Control Sciences
In this work, we give sufficient conditions to get the existence of mild solutions for two classes of first-order semilinear functional and neutral functional perturbed evolution equations with infinite state-dependent delay when the conditions are ...
Selma Baghli-Bendimerad, Imane Abibssi
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Existence of mild solutions of a semilinear evolution differential inclusions with nonlocal conditions

open access: yesElectronic Journal of Differential Equations, 2009
In this paper we prove the existence of a mild solution for a semilinear evolution differential inclusion with nonlocal condition and governed by a family of linear operators, not necessarily bounded or closed, in a Banach space.
Reem A. Al-Omair, Ahmed G. Ibrahim
doaj  

Mild and classical solutions to a fractional singular second order evolution problem

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2012
Existence and uniqueness of mild and classical solutions are discussed for an abstract second-order evolution problem. The nonlinearity contains a local term and a non-local term.
Nasser-Eddine Tatar
doaj   +1 more source

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