Results 41 to 50 of about 74,660 (308)
Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
Advanced Science, EarlyView.In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source
The professional preparation of junior military officers in the Saudi Arabian National Guard : King Khaled Military Academy [PDF]
, 2003 This thesis is a contribution to cross-national studies of professional officer education and training. It describes and evaluates a junior officer preparation programme at King Khaled Military Academy (KKMA), Saudi Arabia, in a comprehensive way.
Al-Otaibi, Tha'ar
core
Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices
Advanced Science, EarlyView.Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen +9 more
wiley +1 more source
Advanced Science, EarlyView.A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
SA Journal of Industrial Psychology, 1996 The psychological contract: Mutual expectations during the join-up phase of military-academical studies. In order to determine the expectations of both the potential students of the Military Academy and the Military Academy itself, Kotter's expectation ...
J. A. Beukes, H. D. Vos
doaj +1 more source
CONTEMPORARY CHALLENGES IN MILITARY EDUCATION – MACEDONIAN MILITARY ACADEMY IN THE CONTEXT
CONTEMPORARY MILITARY CHALLENGES, 2014 This paper evaluates latest reforms in the Macedonian military education system. Both, contemporary challenges in military education and Euro-Atlantic commitment have shaped transformation of military education and training system in the Republic of Macedonia. Hence, these dynamics urged the redefinition of the role and responsibilities of the Military
Angelevski, Slavko, Hadji-Janev, Metodi
openaire +1 more source
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
INFLUENCE OF THE MOTORIC ABILITIES ON MOTORIC EFFICINCY IN MILITARY ACADEMY STUDENTS [PDF]
Sport Mont, 2008 Physical education is part of the curriculum at the Military Academy. It is a complex pedagogical in wich physical exercises are used as the primary means and method of achieving the goals which had been set, and fulfilling the contents of the programme.
Lela Marić, Branko Krsmanović
doaj
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source