Results 101 to 110 of about 577,651 (307)
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Industrial engineering in Spain, the challenge of a new liberal profession in the nineteenth century [PDF]
, 2014 Industrial engineering was established in Spain in 1850. Despite the initial difficulties, the profession found its role in the process of the industrialization of Spain.
Roca Rosell, Antoni Maria Claret
core +1 more source
Advanced Science, EarlyView.The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
MAIN WAYS OF MEDIUM TONNAGE MILITARY VEHICLES DEVELOPMENT [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2017 The main development trends and technical characteristics of medium-tonnage military vehicles in modern armies were analyzed in the article. Based on the analysis carried out there was determined the necessity of vechicle private production and the ...
L. Krainyk, M. Grubel
doaj
Advanced Science, EarlyView.Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang +13 more
wiley +1 more source
SystemsThis research provides an integrated perspective on the application of ergonomics and human factors engineering (HFE) to enhance comfort and efficiency in military transport systems (MTS) and civilian transport systems (CTS), identified as imperative ...
Petruța Blaga +3 more
doaj +1 more source
Electronic collaboration: Some effects of telecommunication media and machine intelligence on team performance [PDF]
Both NASA and DoD have had a long standing interest in teamwork, distributed decision making, and automation. While research on these topics has been pursued independently, it is becoming increasingly clear that the integration of social, cognitive, and ...
Wellens, A. Rodney
core +1 more source
Bridging the Gap: Canadian Engineer Operations at Canal du Nord–Bourlon Wood, 1918 [PDF]
, 2019 During the last hundred days of the Great War, the Allied armies swept eastward past the Hindenburg Line with hammer-blow offensive warfare. Performing their work under intense machine gun and shell fire, engineers erected bridges and constructed roads ...
Pascas, Brian
core +1 more source
Advanced Science, EarlyView.A neural network‐enabled permittivity engineering paradigm is introduced, transcending traditional trial‐and‐error design. By decoupling electromagnetic parameters and screening a high‐throughput feature space, an ultrathin (1.0 mm) magnetic absorber is inversely designed, experimentally achieving a superior and customizable 5.1 GHz bandwidth and ...
Chenxi Liu +9 more
wiley +1 more source
Inclusion of an Introduction to Infrastructure Course in a Civil and Environmental Engineering Curriculum [PDF]
, 2017 Civil infrastructure refers to the built environment (sometimes referred to as public works) and consists of roads, bridges, buildings, dams, levees, drinking water treatment facilities, wastewater treatment facilities, power generation and transmission ...
Behzad, Esmaeili +5 more
core +1 more source