Results 61 to 70 of about 554,352 (317)

Time-dependent alterations of soluble and cellular components in human milk

, 2010
This study sought to determine the chronobiological variations in soluble and cellular components of human breast milk. The material was collected from 36 mothers at three stages of maturity - 3 days (colostrum), 10 days (transitional milk) and 30 days ...
Nicomedes, Tathianne dos Reis, Tathianne dos Reis Nicomedes, Iracema de Mattos Paranhos Calderon, Adenilda Cristina Honorio França, Eduardo Luzía França, Calderon, Iracema de Mattos Paranhos [UNESP], Franca, Eduardo Luzia, Honorio Franca, Adenilda Cristina, Calderon, Iracema de Mattos Paranhos   +8 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Receiving screened donor human milk as part of a community‐based lactation support programme reduces parental symptoms of anxiety and depression

Maternal and Child Nutrition
Infant feeding decisions and maternal mental health are closely tied. Donor human milk (DHM) protects premature infant health and development and can reduce hospital stays.
Amy Brown, Sam Griffin, Gillian Weaver, Natalie Shenker   +3 more
doaj   +1 more source

Paroxetine in human milk [PDF]

British Journal of Clinical Pharmacology, 1999
Aims  The primary aims of the study were to estimate the exposure of infants to paroxetine via breast milk and to determine the maternal milk:plasma ratio (M/P) of paroxetine. Secondary aims were to compare single point and area under the curve (AUC) estimates of M/P, to assess variability of M/P in fore and hind milk, and to ...
E J, Begg, S B, Duffull, D A, Saunders, R C, Buttimore, K F, Ilett, L P, Hackett, P, Yapp, D A, Wilson   +7 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Frontiers in Systems Neuroscience, 2013
Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto, Ryoko eKibe, Takushi eOoga, Yuji eAiba, Emiko eSawaki, Yasuhiro eKoga, Yoshimi eBenno   +6 more
doaj   +1 more source

Quantification of phospholipids and glycerides in human milk using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry

Frontiers in Chemistry, 2023
Human milk lipids, which are an important source of energy and affect growth and development of infants, require a comprehensive method for its qualitative and quantitative analysis.
Yan Liu, Yan Liu, Weicang Qiao, Weicang Qiao, Yanpin Liu, Yanpin Liu, Junying Zhao, Junying Zhao, Qian Liu, Qian Liu, Kai Yang, Kai Yang, Minghui Zhang, Minghui Zhang, Yaling Wang, Yaling Wang, Yan Liu, Yan Liu, Lijun Chen, Lijun Chen   +19 more
doaj   +1 more source

Human milk glycosaminoglycans

, 2013
Glycosaminoglycans (GAGs) are natural complex linear heteropolysaccharides able to regulate many cellular events and physiological processes due to their strong interactive capacity.
D. Buzzega, F. Maccari, F. Galeotti, T. Galeazzi, O. Gabrielli, G. V. Coppa, L. Zampini, L. Padella, N. Volpi, GABRIELLI, ORAZIO, GALEAZZI, Tiziana, ZAMPINI, LUCIA   +11 more
core   +1 more source