Results 71 to 80 of about 36,039 (267)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Scoping review for a research study on consumers' willingness to pay for milk and plant-based milk alternatives- Protocol

, 2023
The purpose of this scoping review is to accomplish five goals. First, the study identifies and evaluates the milk and plant-based milk alternative products and attributes explored in the willingness to pay studies.
Di Minh Duc Tran, Damien Jourdain, Hans De Steur, Margo Degieter, Selma Karuaihe, Pamela Madududu, Herbert Ntuli   +6 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Influence of feed source on determination of fat and protein in milk by near-infrared spectroscopy [PDF]

, 1999
,\ bstract R~.;el v~d 9 September 1998: accepted 10 April 1999 \ !v[lIk s ample~ fr om two experiments (II = 506 in tOlal) were an ,dyzed by measurement of near-infrared (NIR) spectra to investigate the etlect of feed source on milk fat and prolein ...
Purnomoadi, Agung, Ueda, Koichiro, Batajoo, Keshab Kumar, Terada , Fuminori   +3 more
core  

Prions in Milk from Ewes Incubating Natural Scrapie [PDF]

, 2008
Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter unrestricted into the animal and human food chain.
Bergonier Dominique, Fabien Corbière, Lacroux, Caroline, Cassard Hervé, Grassi, Jacques, Andréoletti Olivier, Torffin Moldal, Sylvie L. Benestad, Schelcher, Francois, F., Lugan, Séverine, S., Costes, Pierrette, Benestad Sylvie L., Simmons Hugh, Sylvie L Benestad, Nathalie Morel, Lantier, Frédéric, F., Simon Stéphanie, Lacroux Caroline, Weisbecker, Jean Louis, J. L., Benestad, Sylvie, Hervé Cassard, Bergonier, Dominique, Schelcher, François, Weisbecker, Jean-Louis, Morel, Nathalie, Weisbecker Jean-Louis, Lantier Frederic, Moldal, Torffin, François Schelcher, Stéphanie Simon, Simmons, Hugh, Dominique Bergonier, Morell, Nathalie, Jacques Grassi, Olivier Andréoletti, Schelcher François, Cécile Feraudet-Tarisse, Andréoletti, Olivier, Pierrette Costes, Cassard, Hervé, H., Corbière Fabien, Caroline Lacroux, Maillet, Séverinne, Mathey, Jacinthe, Jean-Louis Weisbecker, Mathey Jacinthe, Hugh Simmons, Cassard, Hervé, Corbière, Fabien, Féraudet-Tarisse, Cécile, Jacinthe Mathey, Feraudet-Tarisse Cécile, Frederic Lantier, Simon, Stéphanie, Séverine Lugan, Séverine Maillet, Morel Nathalie, Costes Pierrette, Costes, Pierrette, P., Lantier, Frédéric, Grassi Jacques, Benestad, Sylvie L, Lugan Séverine, Maillet, Séverine, Moldal Torffin, Lugan, Sévérine, Féraudet, Cécile, Lacroux, Caroline, C., Maillet Séverine   +68 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comprehensive Analysis of Nutritional, Organoleptic, and Functional Aspects of Cow's Milk and Plant-Based Milk Alternatives in the Colombian Market

Vitae
Background: Plant-based beverages, also known as plant-based milk alternatives, are often considered nutritional replacements for conventional cow's milk, as they can serve similar organoleptic and gastronomic purposes.
Ana María Gómez Franco
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source