Results 91 to 100 of about 194,006 (341)

Modelling the Effect of Policy Reform on Structural Change in Irish Farming [PDF]

open access: yes, 2007
End of project reportThe Mid Term Review (MTR) of the Common Agricultural Policy (CAP) has allowed for the decoupling of all direct payments from production from 2005 onwards; until then, most direct payments were coupled to production, requiring farmers
Hennessy, Thia
core  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Brazilian network of human milk banks: a network based on trust

open access: yesRECIIS, 2018
This article bases on a study that aimed to identify the existing links in the rBLH-BR – Rede Brasileira de Bancos de Leite Humano (Brazilian Network of Human Milk Banks).
Mariana Simoes Barros   +2 more
doaj  

Articulation between nursing systems and operational procedures: nursing perspectives of milk banks

open access: yesRevista de Enfermagem da Universidade Federal de Santa Maria, 2017
Aim: to understand the articulation facets of Nursing Care Systematization with the regulations used by nurses of the Human Milk Bank. Method: a descriptive study of a qualitative approach, carried out from May to November2014, inthe seven milk banks of ...
Giovanna Rosario Soanno Marchiori   +5 more
doaj   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu   +14 more
wiley   +1 more source

The balance sheet of agriculture, 1954 [PDF]

open access: yes
Agriculture - Economic ...
F.L. Garlock   +3 more
core  

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang   +16 more
wiley   +1 more source

How infrastructure and financial institutions affect agricultural output and investment in India [PDF]

open access: yes
How do the decisions of farmers, financial institutions, and government agencies interact and affect agricultural investment and output in a region - and to what extent are these"actors"influenced by a region's location and agroclimactic endowments (for ...
Binswanger, Hans P.   +2 more
core  

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