Results 91 to 100 of about 1,716,846 (311)

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Modelling the Effect of Policy Reform on Structural Change in Irish Farming [PDF]

, 2007
End of project reportThe Mid Term Review (MTR) of the Common Agricultural Policy (CAP) has allowed for the decoupling of all direct payments from production from 2005 onwards; until then, most direct payments were coupled to production, requiring farmers
Hennessy, Thia
core  

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

The dialog between health and foreign policy in Brazilian cooperation in human milk banks.

Ciência & Saúde Coletiva, 2017
Mother's milk is the primary source of nourishment in early infancy. When this source is unavailable, secondary sources may be used, such as human milk banks. The first milk bank in Brazil was created in 1943, and they have been used ever since.
Tiago Mocellin Pittas, C. Dri
semanticscholar   +1 more source

Texas Business Review, January 1976 [PDF]

, 1976
The Business Situation in Texas; The Last Hundred Years; The Next Hundred Years; Electric Funds Transference: Development and Prospects; Texas Construction: Four Decades of ChangeBureau of Business ...
Adair, Bryan, Crum, Lawrence L., Lockwood, Robert M., Ryan, Robert H.   +3 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Brazilian network of human milk banks: a network based on trust

RECIIS, 2018
This article bases on a study that aimed to identify the existing links in the rBLH-BR – Rede Brasileira de Bancos de Leite Humano (Brazilian Network of Human Milk Banks).
Mariana Simoes Barros, João Aprigio Guerra de Almeida, Alejandro Guillermo Rabuffetti   +2 more
doaj  

How infrastructure and financial institutions affect agricultural output and investment in India [PDF]

How do the decisions of farmers, financial institutions, and government agencies interact and affect agricultural investment and output in a region - and to what extent are these"actors"influenced by a region's location and agroclimactic endowments (for ...
Binswanger, Hans P., Khandker, Shahidur R, Rosenzweig, Mark R.   +2 more
core  

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Articulation between nursing systems and operational procedures: nursing perspectives of milk banks

Revista de Enfermagem da Universidade Federal de Santa Maria, 2017
Aim: to understand the articulation facets of Nursing Care Systematization with the regulations used by nurses of the Human Milk Bank. Method: a descriptive study of a qualitative approach, carried out from May to November2014, inthe seven milk banks of ...
Giovanna Rosario Soanno Marchiori, Valdecyr Herdy Alves, Diego Pereira Rodrigues, Adriana Duarte Gabriel, Marcia Vieira dos Santos, Maria Bertilla Lutterbach Riker Branco   +5 more
doaj   +1 more source