Results 81 to 90 of about 242,756 (263)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

Whole cottonseed increases milk fat, decreases milk protein

open access: yesCalifornia Agriculture, 1985
In diets of milking cows, whole cottonseed produced more fat and solids but less total protein.
E DePeters, S Taylor, A Aguirre
doaj  

EVALUATION OF HOLSTEIN CROSSBRED BULLS ON THE BASIS OF MILK FAT CONTENT OF DAUGHTERS [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2006
Ten Holstein-Friesian crossbred bulls, ranging in exotic inheritance from 50-75% were evaluated for milk fat content using Simple Daughters Average, Contemporary Compa rison and Least Squares Means. The data on milk fat content of 103 progenies in their
G. Radhika, S. lype, M. Stephen
doaj  

The Skinny on Low-fat and Fat-free Milk and Milk Products

open access: yesEDIS, 2011
Whether you are young or old, consuming fat-free and low-fat milk products every day is important for good health. This 5-page fact sheet highlights the purpose of including foods from the Milk group in the diet and the daily amounts needed for children and adults. It also includes helpful hints for those who are lactose intolerant.
Lauren Headrick, Karla P. Shelnutt
openaire   +3 more sources

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv   +16 more
wiley   +1 more source

Effect of a blend of palmitic and stearic acid on transfer of preformed fatty acids into milk fat using an 18 C n-3 fatty acid perturbation model

open access: yesJournal of Dairy Science
: The transfer of dietary fatty acids (FA) into milk fat is variable and has been reported to be higher on lower fat diets, which may be a homeorhetic adaptation to support milk fat production.
Y.A. Adeniji   +3 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao   +12 more
wiley   +1 more source

KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells

open access: yesiScience
Summary: Milk fat is an important indicator for evaluating the quality of cow’s milk. In this study, we used bovine mammary epithelial cells (BMECs) to investigate the role and molecular mechanism of KLF4 in the regulation of milk fat synthesis.
Hong-Yu Wu   +6 more
doaj   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

open access: yesAdvanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi   +11 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

open access: yesAdvanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang   +11 more
wiley   +1 more source

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