Advanced Science, EarlyView.NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang +8 more
wiley +1 more source
Estimation of Genetic Parameters and Stability for Milk Production Traits in Huaxi Cattle from the Xinjiang Region. [PDF]
Animals (Basel)Feng Y +8 more
europepmc +1 more source
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source
Evaluating High Ambient Temperature Effects on Milk Production in Local Tunisian Goats: Toward Resilient Breeding Strategies for Arid Environments. [PDF]
Animals (Basel)Atoui A +5 more
europepmc +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source
Milk Production, Composition, and Reproductive Performance of Crossbred Dairy Stock on Smallholder Dairying in Ethiopia. [PDF]
Food Sci Anim ResourAbate A, Didanna HL, Ayza A.
europepmc +1 more source
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
ИЗУЧЕНИЕ ОСТРОЙ ПЕРОРАЛЬНОЙ ТОКСИЧНОСТИ ХЛОРИСТОГО КАЛИЯ НА БЕЛЫХ ЛАБОРАТОРНЫХ КРЫСАХ
Ветеринарная патология, 2019 Ivan Fedorovich Gorlov +8 more
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Back Acupressure, Baby Positioning and Latching, and Breast Massage Increase Breast Milk Production: A Controlled Clinical Trial. [PDF]
Acta Med PhilippPujiastuti N, Winarni S.
europepmc +1 more source
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source