Results 21 to 30 of about 373,268 (263)

Polymorphism of CLPG gene in three sheep breeds grown in the steppe zone of the Russian Federation

Journal of Advanced Veterinary and Animal Research, 2020
Objective: This study aims to investigate the callipyge gene (CLPG) polymorphism in sheep of Edilbay, Volgograd, and Kalmyk breeds. Materials and Methods: The analysis was performed by the polymerase chain reaction–restric¬tion fragment length ...
Ivan Fiodorovich Gorlov, Nadezhda Vasilievna Shirokova, Yuri Anatolievich Kolosov, Anatoli Yurievich Kolosov, Lyubov Vladimirovna Getmantseva, Marina Ivanovna Slozhenkina, Natalia Ivanovna Mosolova, Elena Yurievna Anisimova, Viktor Vladimirovich Ponomariov   +8 more
doaj   +1 more source

Exploration of non-coding RNAs related to intramuscular fat deposition in Xinjiang Brown cattle and Angus × Wagyu cattle

BMC Genomics
Non-coding RNAs (ncRNAs) serve as crucial regulatory elements in the process of adipogenesis in animals; however, the specific roles and interrelationships of ncRNAs in bovine fat deposition remain poorly understood.
Yuxin Zhou, Wanping Ren, Wei Shao, Yu Gao, Kangyu Yao, Min Yang, Xinyu Zhang, Yiran Wang, Fengming Li, Liang Yang   +9 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Effects of additional colostrum feeding on the levels of protein fractions in calves’ serum

Mljekarstvo, 2019
The aim of this study was to investigate the impact of additional colostrum feeding to new born calves on levels of selected serum protein fractions. The study was conducted on a commercial dairy farm.
Edyta Wojtas, Marta Iwaszkiewicz, Andrzej Zachwieja, Ewa Pecka-Kiełb, Katarzyna Paczyńska, Joanna Tumanowicz   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Review: the influence of genotypic and phenotypic factors on the comfort and welfare rates of cows during the period of global climate changes

Agraarteadus, 2021
The study of the influence of weather phenomena on behavioural and physiological processes plays an important role in the development of highly effective methods of dairy farming management. Climate and weather factors have important signification in the
Oleksandr O. Borshch, Serhii Ruban, Oleksandr V. Borshch   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source