Results 51 to 60 of about 408,363 (241)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Milk Replacer Supplementation with Docosahexaenoic Acid from Microalgae Does Not Affect Growth and Immune Status in Goat Kids

Animals, 2020
Consumption of polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA), has beneficial effects for consumers’ health. Consequently, there is an increased interest in enhancing meat fatty acid profiles (i.e., PUFA and DHA content ...
Isabel Moreno-Indias, Lorenzo E. Hernández-Castellano, Davinia Sánchez-Macías, Antonio Morales-delaNuez, Alexandr Torres, Anastasio Argüello, Noemí Castro   +6 more
doaj   +1 more source

Survey of biochemical and oxidative profile in donkey foals suckled with one natural and one semi-artificial technique. [PDF]

PLoS ONE, 2018
Dairy donkey milking procedures require separating foals from their dams for a few hours a day. Artificial suckling in this species is a good technique for improving milk production and foal welfare.
Pasquale De Palo, Aristide Maggiolino, Marzia Albenzio, Elisabetta Casalino, Gianluca Neglia, Gerardo Centoducati, Alessandra Tateo   +6 more
doaj   +1 more source

Effect of replacing milk products with a soybean protein isolate milk replacer in diets for nursery pigs [PDF]

, 1989
One hundred eighty pigs (21 d of age and averaging 14.5 lb) were used to determine if a milk replacer containing soybean protein isolate can replace dried skim milk and dried whey in a high nutrient density starter diet.
Jim L Nelssen, Hancock, Joe D., Jones, D.B., Joe D Hancock, Hancock, Joe D, Li, D F, Nelssen, Jim L, Li, D.F., Jones, D B, D B Jones, Nelssen, Jim L., D F Li   +11 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Growth and body composition of dairy calves fed only milk replacer at 3 intakes

Journal of Dairy Science
: Determination of energy requirements for growth depends on measuring the composition of BW gain. Previous studies have shown that the composition of gain can be altered in young dairy calves by the composition of the milk replacer diet.
K.S. Bartlett, F.K. McKeith, R.A. Molano, M.E. Van Amburgh, M.J. VandeHaar, G.E. Dahl, J.K. Drackley   +6 more
doaj   +1 more source

Milk intake and carbon dioxide production of piglets determined with the doubly labelled water technique

Animal, 2007
The present study was undertaken to study different methodological aspects of quantifying CO2 production and milk intake of suckling piglets using the doubly labelled water (DLW) technique. In total, 37 piglets were enriched intraperitoneally with DLW to
P.K. Theil, N.B. Kristensen, H. Jørgensen, R. Labouriau, K. Jakobsen   +4 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Pre-weaning growth performance of Etawah Crossbred goats fed milk replacer [PDF]

, 2013
In this experiment the effect of feeding milk replacer and dairy milk on the growth performance of pre-weaning of Etawah Crossbred goats was studied. Thirty eight heads of pre-weaning of Etawah Crossbred kids were divided into 2 groups, Group A receiving
., Supriyati
core   +1 more source