Results 31 to 40 of about 151,078 (334)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Generalized Rotation Curves of the Milky Way from the GAIA DR3 Data Set: Constraints on Mass Models

The Astrophysical Journal
The circular velocity curve traced by stars provides a direct means of investigating the potential and mass distribution of the Milky Way. Recent measurements of the Galaxy’s rotation curve have revealed a significant decrease in velocity for Galactic ...
Francesco Sylos Labini
doaj   +1 more source

Planetary nebulae in the inner Milky Way [PDF]

, 2009
New abundances of planetary nebulae located towards the bulge of the Galaxy are derived based on observations made at LNA (Brazil). We present accurate abundances of the elements He, N, S, O, Ar, and Ne for 56 PNe located towards the galactic bulge.
Chiappini, Costa, Cuisinier, Escudero, Oscar Cavichia, Roberto D. D. Costa, Smartt, Walter J. Maciel   +7 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

VISTA Milky Way public survey [PDF]

, 2009
We propose a public IR variability survey, named \Vista Variables in the Vía Láctea" (V V V ), of the Milky Way bulge and an adjacent section of the mid-plane where star formation activity is high. This would take 1920 hours, covering ~ 109 point sources
Adamson, A., Ahumada, A. V., Bandyopadhyay, R., Barbuy, B., Barbá, R. H., Barlow, M., Bedin, L., Bica, E., Borissova, J., Bronfman, L., Carraro, G., Casassus, S., CASU (VDFS) team, The, Catelan, M., Clariá, J. J., Cropper, M., de Grijs, R., Drew, J., Eisloeffel, J., Emerson, J., Fabregat, J., Gamen, R., Geisler, D., Gianinni, T., Gieren, W., Goldman, B., Gosling, A., Groot, P., Hambly, N., Hoare, M., Hodgkin, S., Ivanov, V. D., Kerins, E., Kurtev, R., Longmore, A., Lucas, P., Lucey, J., López-Correidora, M., Martin, E., McGowan, K., Mennickent, R. E., Messineo, M., Minniti, D., Mirabel, F., Monaco, L., Morelli, L., Naylor, T., Pietrzynski, G., Pignata, G., Pinfield, D., Rejkuba, M., Ruiz, M. T., Saviane, I., Schroeder, A., Stephens, A., Tapper, C., Thompson, M., Toledo, I., Vanzi, L., Walton, N., WFAU (VDFS) team, The, White, G., Zijlstra, A., Zoccali, M.   +63 more
core   +2 more sources

Outer Regions of the Milky Way

, 2017
With the start of the Gaia era, the time has come to address the major challenge of deriving the star formation history and evolution of the disk of our MilkyWay. Here we review our present knowledge of the outer regions of the Milky Way disk population.
A. Toomre, B.F. Burke, C.C. Lin, G. Westerhout, H.C. Harris, H.J. Rocha-Pinto, I. García-Ruiz, J. Binney, J.A. Sellwood, O.J. Eggen, P.A. Patsis, P.C. Kruit van der   +11 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Cosmological Structures behind the Milky Way

, 2005
This paper provides an update to the review on extragalactic large-scale structures uncovered in the Zone of Avoidance (ZOA) by Kraan-Korteweg & Lahav 2000, in particular in the Great Attractor region. Emphasis is given to the penetration of the ZOA with
Kraan-Korteweg, Renee C.
core   +1 more source

Milky Way dust extinction measured with QSOs [PDF]

, 2014
We investigate reddening by Milky Way dust in the low-extinction regime of $E_{B-V}
Wolf, Christian
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source