Results 31 to 40 of about 152,178 (295)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The spiral potential of the Milky Way [PDF]

, 2018
Context. The location of young sources in the Galaxy suggests a four-armed spiral structure, whereas tangential points of spiral arms observed in the integrated light at infrared and radio wavelengths indicate that only two arms are massive.
Carraro, G., Grosb\uf8l, P.
core   +2 more sources

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

Mapping the Milky Way Disk with Gaia DR3: 3D Extended Kinematic Maps and Rotation Curve to ≈30 kpc

The Astrophysical Journal, 2022
We apply a statistical deconvolution of the parallax errors based on Lucy’s inversion method (LIM) to the Gaia DR3 sources to measure their 3D velocity components in the range of Galactocentric distances R between 8 and 30 kpc with their corresponding ...
Hai-Feng Wang, Žofia Chrobáková, Martín López-Corredoira, Francesco Sylos Labini   +3 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Additional Evidence for the Existence of a Primordial Disk System

The Astrophysical Journal
The origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu, Haibo Yuan, Bowen Huang, Timothy C. Beers, Yang Huang, Maosheng Xiang, Kai Xiao, Jihye Hong, Young Sun Lee, Wuming Yang   +9 more
doaj   +1 more source

Mass Models of the Milky Way and Estimation of Its Mass from the Gaia DR3 Data Set

The Astrophysical Journal, 2023
We use data from the Gaia DR3 data set to estimate the mass of the Milky Way (MW) by analyzing the rotation curve in the range of distances 5 to 28 kpc. We consider three mass models: The first model adds a spherical dark matter (DM) halo, following the ...
Francesco Sylos Labini, Žofia Chrobáková, Roberto Capuzzo-Dolcetta, Martín López-Corredoira   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Cosmological Structures behind the Milky Way

, 2005
This paper provides an update to the review on extragalactic large-scale structures uncovered in the Zone of Avoidance (ZOA) by Kraan-Korteweg & Lahav 2000, in particular in the Great Attractor region. Emphasis is given to the penetration of the ZOA with
Kraan-Korteweg, Renee C.
core   +1 more source

The origin of the Milky Way globular clusters [PDF]

, 2016
We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters ...
Agertz, Oscar, Gieles, Mark, Renaud, Florent   +2 more
core   +2 more sources