Results 31 to 40 of about 23,339 (302)
Generalized Rotation Curves of the Milky Way from the GAIA DR3 Data Set: Constraints on Mass Models
The Astrophysical JournalThe circular velocity curve traced by stars provides a direct means of investigating the potential and mass distribution of the Milky Way. Recent measurements of the Galaxy’s rotation curve have revealed a significant decrease in velocity for Galactic ...
Francesco Sylos Labini
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys
The Astrophysical Journal Supplement SeriesPhotometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong +17 more
doaj +1 more source
Mapping the Milky Way Disk with Gaia DR3: 3D Extended Kinematic Maps and Rotation Curve to ≈30 kpc
The Astrophysical Journal, 2022 We apply a statistical deconvolution of the parallax errors based on Lucy’s inversion method (LIM) to the Gaia DR3 sources to measure their 3D velocity components in the range of Galactocentric distances R between 8 and 30 kpc with their corresponding ...
Hai-Feng Wang +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Additional Evidence for the Existence of a Primordial Disk System
The Astrophysical JournalThe origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu +9 more
doaj +1 more source
Mass Models of the Milky Way and Estimation of Its Mass from the Gaia DR3 Data Set
The Astrophysical Journal, 2023 We use data from the Gaia DR3 data set to estimate the mass of the Milky Way (MW) by analyzing the rotation curve in the range of distances 5 to 28 kpc. We consider three mass models: The first model adds a spherical dark matter (DM) halo, following the ...
Francesco Sylos Labini +3 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source