Results 31 to 40 of about 147,087 (317)

Mapping the Milky Way Disk with Gaia DR3: 3D Extended Kinematic Maps and Rotation Curve to ≈30 kpc

The Astrophysical Journal, 2022
We apply a statistical deconvolution of the parallax errors based on Lucy’s inversion method (LIM) to the Gaia DR3 sources to measure their 3D velocity components in the range of Galactocentric distances R between 8 and 30 kpc with their corresponding ...
Hai-Feng Wang, Žofia Chrobáková, Martín López-Corredoira, Francesco Sylos Labini   +3 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Generalized Rotation Curves of the Milky Way from the GAIA DR3 Data Set: Constraints on Mass Models

The Astrophysical Journal
The circular velocity curve traced by stars provides a direct means of investigating the potential and mass distribution of the Milky Way. Recent measurements of the Galaxy’s rotation curve have revealed a significant decrease in velocity for Galactic ...
Francesco Sylos Labini
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

The infant Milky Way [PDF]

, 2012
We investigate the physical properties of the progenitors of today living Milky Way-like galaxies that are visible as Damped Lya Absorption systems and Lya Emitters at higher redshifts (z ~ 2.3,5.7).
Ferrara, Andrea, Salvadori, Stefania
core   +3 more sources

Cosmological Structures behind the Milky Way

, 2005
This paper provides an update to the review on extragalactic large-scale structures uncovered in the Zone of Avoidance (ZOA) by Kraan-Korteweg & Lahav 2000, in particular in the Great Attractor region. Emphasis is given to the penetration of the ZOA with
Kraan-Korteweg, Renee C.
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Milky Way Mass Models and MOND

, 2008
Using the Tuorla-Heidelberg model for the mass distribution of the Milky Way, I determine the rotation curve predicted by MOND. The result is in good agreement with the observed terminal velocities interior to the solar radius and with estimates of the ...
Angus G. W., Begeman K. G., Binney J., Binney J., Brada R., Broeils A. H., de Blok W. J. G., Famaey B., Famaey B., Feast M., Gerhard O., Hayashi E., Iorio L., Kerr F. J., Pointecouteau E., Sanders R. H., Stacy S. McGaugh   +16 more
core   +1 more source

Stellar Bars in Isolated Gas-rich Spiral Galaxies Do Not Slow Down

The Astrophysical Journal, 2023
Elongated bar-like features are ubiquitous in galaxies, occurring at the centers of approximately two-thirds of spiral disks in the nearby Universe. Due to gravitational interactions between the bar and the other components of galaxies, it is expected ...
Angus Beane, Lars Hernquist, Elena D’Onghia, Federico Marinacci, Charlie Conroy, Jia Qi, Laura V. Sales, Paul Torrey, Mark Vogelsberger   +8 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source