Results 51 to 60 of about 147,116 (290)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Milky Way’s Rowdy Neighbors: The Effects of the Large Magellanic Cloud and Sagittarius Dwarf on the Milky Way Disk

The Astrophysical Journal
The Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea, Jason A. S. Hunt, Kathryn V. Johnston   +2 more
doaj   +1 more source

The SAGA Survey: I. Satellite Galaxy Populations Around Eight Milky Way Analogs

, 2017
We present the survey strategy and early results of the "Satellites Around Galactic Analogs" (SAGA) Survey. The SAGA Survey's goal is to measure the distribution of satellite galaxies around 100 systems analogous to the Milky Way down to the luminosity ...
Bernstein, Rebecca, Geha, Marla, Hoyle, Ben, Lu, Yu, Mao, Yao-Yuan, Marchi, Sebastian, Marshall, Phil J., Munoz, Ricardo, Tollerud, Erik J., Wechsler, Risa H., Weiner, Benjamin   +10 more
core   +1 more source

Dust Emissivity Variations In the Milky Way [PDF]

, 2009
Dust properties appear to vary according to the environment in which the dust evolves. Previous observational indications of these variations in the FIR and submm spectral range are scarce and limited to specific regions of the sky.
Abergel, Abergel, Allamandola, Bacmann, Bazell, Bennett, Bernard, Boulanger, Boulanger, C. Mény, Cambrésy, Cambrésy, Cambrésy, Caselli, D. Paradis, Dale, Dame, Delabrouille, Dickey, Draine, Draine, Dupac, Désert, Finkbeiner, Fixsen, Fixsen, J.-Ph. Bernard, Kemper, Lagache, Laureijs, Laureijs, Laureijs, Macias-Perez, Magnani, Mathis, Mény, Puget, Stepnik, Stepnik, Strong, Tielens, Tielens, Tristram, Van de Bult   +43 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

Mapping the Milky Way Disk with Gaia DR3: 3D Extended Kinematic Maps and Rotation Curve to ≈30 kpc

The Astrophysical Journal, 2022
We apply a statistical deconvolution of the parallax errors based on Lucy’s inversion method (LIM) to the Gaia DR3 sources to measure their 3D velocity components in the range of Galactocentric distances R between 8 and 30 kpc with their corresponding ...
Hai-Feng Wang, Žofia Chrobáková, Martín López-Corredoira, Francesco Sylos Labini   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mass Models of the Milky Way and Estimation of Its Mass from the Gaia DR3 Data Set

The Astrophysical Journal, 2023
We use data from the Gaia DR3 data set to estimate the mass of the Milky Way (MW) by analyzing the rotation curve in the range of distances 5 to 28 kpc. We consider three mass models: The first model adds a spherical dark matter (DM) halo, following the ...
Francesco Sylos Labini, Žofia Chrobáková, Roberto Capuzzo-Dolcetta, Martín López-Corredoira   +3 more
doaj   +1 more source

How Common are the Magellanic Clouds? [PDF]

, 2011
We introduce a probabilistic approach to the problem of counting dwarf satellites around host galaxies in databases with limited redshift information.
Abazajian, Belokurov, Besla, Blanton, Blanton, Blanton, Brian F. Gerke, Bullock, Busha, Busha, Busha, Chen, Conroy, Conroy, Holmberg, Klypin, Klypin, Klypin, Koposov, Lorrimer, Lulu Liu, Madau, Michael T. Busha, Moore, Oyaizu, Peter S. Behroozi, Prada, Risa H. Wechsler, Strateva, Tollerud, Walsh, Wechsler, York, Zehavi   +33 more
core   +2 more sources