Results 61 to 70 of about 147,116 (290)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The Astrophysical JournalWe present a novel, deep-learning-based method—dubbed Galactic-Seismology Substructures and Streams Hunter, or GS ^3 Hunter for short—to search for substructures and streams in stellar kinematics data.
Guan-Yu Wang +6 more
doaj +1 more source
Milky Way dust extinction measured with QSOs [PDF]
, 2014 We investigate reddening by Milky Way dust in the low-extinction regime of $E_{B-V}
Wolf, Christian
core +1 more source
This chapter reviews the three-dimensional structure, age, kinematics, and chemistry of the Milky Way (MW) region within ~2 kpc from its center (hereafter referred to as the 'bulge') from an observational perspective. While not exhaustive in citations, this review provides historical context and discusses the main controversies and limitations in the ...
Zoccali, Manuela, Valenti, Elena
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Astrophysical JournalUnderstanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo +10 more
doaj +1 more source
The Astrophysical Journal, 2023 We present a Galactic disk vertical velocity analysis using OB type stars (OB stars), red clump (RC) stars, and main-sequence turnoff (MSTO) stars with different average age populations crossmatched with LAMOST DR5 and Gaia DR3. We show that the vertical
Xiang Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source