Results 81 to 90 of about 147,116 (290)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A 3D Chemodynamical Census of Inner-Galaxy Metal-poor Giants to [Fe/H] ∼ −3.5

The Astrophysical Journal Letters
The earliest assembly of the Milky Way remains poorly understood, yet the spatial, chemical, and kinematic properties of its most metal-poor stars provide a unique fossil record of its proto-Galaxy phase.
Shenglan Sun, Yang Huang, Fangzhou Jiang, Huawei Zhang, Xiang-Xiang Xue, Timothy C. Beers, Chengye Cao, Qikang Feng, Ruizhi Zhang, Haiyang Xing, João A. S. Amarante   +10 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Signatures of a Tidally Induced Spiral Arm at the Anticenter of the Milky Way and a Kinematically Extended Anticenter Stream Using DESI Data Release 2

The Astronomical Journal
Using the Dark Energy Spectroscopic Instrument (DESI) Milky Way Survey, we examine the six-dimensional space of the anticenter region of the Milky Way stellar disk (150° < Galactic longitude < 220°) using 61,883 main-sequence turnoff stars.
Mika Lambert, Constance M. Rockosi, Sergey E. Koposov, Ting S. Li, Monica Valluri, Leandro Beraldo e Silva, Songting Li, João A. S. Amarante, Amanda Byström, Gustavo E. Medina, Nathan R. Sandford, Joan Najita, Namitha Kizhuprakkat, Jessica N. Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Kyle Dawson, Axel de la Macorra, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Richard Joyce, Anthony Kremin, Claire Lamman, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, John Moustakas, Adam Myers, Seshadri Nadathur, Will Percival, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Joseph H. Silber, David Sprayberry, Gregory Tarlé, Benjamin A. Weaver, Rongpu Zhou, Hu Zou   +48 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source

Milky Way halo gas kinematics [PDF]

Measurements of high resolution, short wavelength absorption data taken by IUE toward high latitude O and B stars are presented in a discussion of the large scale kinematic properties of Milky Way Halo gas. An analysis of these data demonstrates that: (1)
Danly, L.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

HR-GO. II. Chemical Abundances of Low-E Retrograde Dynamically Tagged Groups: Revealing Thamnos as a Very Metal-poor Substructure

The Astrophysical Journal
Milky Way halo substructures identified in dynamical space are known to suffer from contamination from the Milky Way in situ stars, which makes their accreted origins uncertain. We present detailed chemical abundances of 35 stars belonging to two sets of
Renjing Xie, Zhen Yuan, Haining Li, Tadafumi Matsuno, Nicolas F. Martin, Ruizhi Zhang, Zhiqiang Yan, Federico Sestito, Guillaume F. Thomas, Projjwal Banerjee, Ruizheng Jiang, Linda Lombardo, David S. Aguado, Kohei Hattori, Gang Zhao   +14 more
doaj   +1 more source

The Galactic Bulge: A Review

, 2007
The Milky Way is the only galaxy for which we can resolve individual stars at all evolutionary phases, from the Galactic center to the outskirt. The last decade, thanks to the advent of near IR detectors and 8 meter class telescopes, has seen a great ...
Alard, Alves-Brito, Barbuy, Barbuy, Barbuy, Bica, Dante Minniti, Dwek, Hamadache, Harding, Immeli, Lecureur, Manuela Zoccali, Zoccali, Zoccali, Zoccali   +15 more
core   +1 more source