Results 81 to 90 of about 5,448,204 (296)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way

The Astrophysical Journal
The search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin, Alessandro Spagna, Mario G. Lattanzi, Michele Cignoni, Sara Vitali   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

A 3D Chemodynamical Census of Inner-Galaxy Metal-poor Giants to [Fe/H] ∼ −3.5

The Astrophysical Journal Letters
The earliest assembly of the Milky Way remains poorly understood, yet the spatial, chemical, and kinematic properties of its most metal-poor stars provide a unique fossil record of its proto-Galaxy phase.
Shenglan Sun, Yang Huang, Fangzhou Jiang, Huawei Zhang, Xiang-Xiang Xue, Timothy C. Beers, Chengye Cao, Qikang Feng, Ruizhi Zhang, Haiyang Xing, João A. S. Amarante   +10 more
doaj   +1 more source

The Milky Way bulge

This chapter reviews the three-dimensional structure, age, kinematics, and chemistry of the Milky Way (MW) region within ~2 kpc from its center (hereafter referred to as the 'bulge') from an observational perspective. While not exhaustive in citations, this review provides historical context and discusses the main controversies and limitations in the ...
Zoccali, Manuela, Valenti, Elena
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Milky Way Bone Masks

Masks for the Milky Way Bone filaments used in Zucker, Battersby, & Goodman 2018 (submitted). Original characterization of the Milky Way Bones can be found in Zucker, Battersby, & Goodman 2015.
Zucker, Catherine
core   +2 more sources

Milky way

Emic
Section divider: Milky Way.
Athena Sharifi-Razavi, Amir Moghadam Ahmadi, Ashkan Mowla   +2 more
openaire   +2 more sources

Signatures of a Tidally Induced Spiral Arm at the Anticenter of the Milky Way and a Kinematically Extended Anticenter Stream Using DESI Data Release 2

The Astronomical Journal
Using the Dark Energy Spectroscopic Instrument (DESI) Milky Way Survey, we examine the six-dimensional space of the anticenter region of the Milky Way stellar disk (150° < Galactic longitude < 220°) using 61,883 main-sequence turnoff stars.
Mika Lambert, Constance M. Rockosi, Sergey E. Koposov, Ting S. Li, Monica Valluri, Leandro Beraldo e Silva, Songting Li, João A. S. Amarante, Amanda Byström, Gustavo E. Medina, Nathan R. Sandford, Joan Najita, Namitha Kizhuprakkat, Jessica N. Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Kyle Dawson, Axel de la Macorra, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Richard Joyce, Anthony Kremin, Claire Lamman, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, John Moustakas, Adam Myers, Seshadri Nadathur, Will Percival, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Joseph H. Silber, David Sprayberry, Gregory Tarlé, Benjamin A. Weaver, Rongpu Zhou, Hu Zou   +48 more
doaj   +1 more source

TRILEGAL, a TRIdimensional modeL of thE GALaxy: Status and FutureRed Giants as Probes of the Structure and Evolution of the Milky Way

, 2012
We briefly describe TRILEGAL, a TRIdimensional modeL of thE GALaxy, and its more recent developments. Particularly relevant is the recent inclusion of a kinematical module to the code, and the present efforts to provide a more solid calibration of Milky ...
Barbieri, Mauro, Groenewegen, Martin A. T., Santiago, Basílio X., da Costa, Luiz N., Bressan, Alessandro, Rocha Pinto, Helio J., Camargo, Julio I. B., Girardi, Léo, MARIGO, PAOLA   +8 more
core   +1 more source