Results 91 to 100 of about 5,448,204 (296)
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
The Orbital Anisotropy Profile of the Gaia-Sausage/Enceladus Accretion Remnant
The Astrophysical JournalThe Gaia - Sausage/Enceladus (GS/E) accretion remnant is one of the most important stellar populations in the Milky Way halo. Recent simulation-based work has suggested that the anisotropy profiles of remnants like GS/E decline towards the center and may
James M. M. Lane, Jo Bovy
doaj +1 more source
4-H Group Visiting Cows at Milky Way Farms
, 1986 Young 4-H members visit the cows at Cecil Reagan's Milky Way Farms.
The Bradenton Herald
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, 2021 The photographs are mostly of the Australian National University campus, including Mount Stromlo and Siding Spring. There are aerial photographs of the Acton site at different times, and photographs of events and portraits.
ANU Photographic Services
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FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
, 2011 We present the first systematic comparison of the detailed properties, including internal kinematics, chemical abundances, sizes, and dark matter masses, of Milky Way and M 31 dSphs as a part of the SPLASH Survey (Spectroscopic and Photometric Landscape ...
R.J. Patterson +9 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
The Rapid Formation of the Metal-poor Milky Way
The Astrophysical JournalOur understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Rebecca Woody +8 more
doaj +1 more source
, 2018 The Milky Way is made up of a central bar, a disk with embedded spiral arms, and a dark matter halo. Observational and theoretical constraints for the characteristic parameters of these components will be presented, with emphasis on the constraints from ...
Gerhard, Ortwin, Englmaier, Peter
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Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source