Results 91 to 100 of about 147,116 (290)
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
4MOST Consortium Survey 3: Milky Way Disc and Bulge Low-Resolution Survey (4MIDABLE-LR)
, 2019 The mechanisms of the formation and evolution of the Milky Way are encoded in the orbits, chemistry and ages of its stars. With the 4MOST MIlky way Disk And BuLgE Low-Resolution Survey (4MIDABLE-LR) we aim to study kinematic and chemical substructures in
Anders, F. +38 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
HI shells in the outer Milky Way
, 2005 We present results of a method for an automatic search for HI shells in 3D data cubes and apply it to the Leiden-Dwingeloo HI survey of the northern Milky Way.
Ehlerova, S., Palous, J.
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
The Astrophysical JournalThe phase spiral is a perturbation to the vertical phase-space distribution of stars in the Milky Way disk. We study the phase spiral’s properties and how they vary with spatial position, in order to constrain its origin and evolution, as well as ...
Axel Widmark +4 more
doaj +1 more source
Dynamical Models for the Milky Way
, 1996 The only way to map the Galaxy's gravitational potential $\Phi({\bf x})$ and the distribution of matter that produces it is by modelling the dynamics of stars and gas. Observations of the kinematics of gas provide key information about gradients of $\Phi$
Binney, James, Dehnen, Walter
core
, 2012 We investigate the physical properties of the progenitors of today living Milky Way-like galaxies that are visible as Damped Lya Absorption systems and Lya Emitters at higher redshifts (z ~ 2.3,5.7).
Ferrara, Andrea, Salvadori, Stefania
core +3 more sources