Results 51 to 60 of about 151,078 (334)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

The Galactic Bulge: A Review

, 2007
The Milky Way is the only galaxy for which we can resolve individual stars at all evolutionary phases, from the Galactic center to the outskirt. The last decade, thanks to the advent of near IR detectors and 8 meter class telescopes, has seen a great ...
Alard, Alves-Brito, Barbuy, Barbuy, Barbuy, Bica, Dante Minniti, Dwek, Hamadache, Harding, Immeli, Lecureur, Manuela Zoccali, Zoccali, Zoccali, Zoccali   +15 more
core   +1 more source

The spiral potential of the Milky Way [PDF]

, 2018
Context. The location of young sources in the Galaxy suggests a four-armed spiral structure, whereas tangential points of spiral arms observed in the integrated light at infrared and radio wavelengths indicate that only two arms are massive.
Carraro, G., Grosb\uf8l, P.
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evidence for Population-dependent Vertical Motions and the Long-lived Nonsteady Lopsided Milky Way Warp

The Astrophysical Journal, 2023
We present a Galactic disk vertical velocity analysis using OB type stars (OB stars), red clump (RC) stars, and main-sequence turnoff (MSTO) stars with different average age populations crossmatched with LAMOST DR5 and Gaia DR3. We show that the vertical
Xiang Li, Hai-Feng Wang, Yang-Ping Luo, Martín López-Corredoira, Yuan-Sen Ting, Žofia Chrobáková   +5 more
doaj   +1 more source

HI shells in the outer Milky Way

, 2005
We present results of a method for an automatic search for HI shells in 3D data cubes and apply it to the Leiden-Dwingeloo HI survey of the northern Milky Way.
Ehlerova, S., Palous, J.
core   +1 more source

The origin of the Milky Way globular clusters [PDF]

, 2016
We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters ...
Agertz, Oscar, Gieles, Mark, Renaud, Florent   +2 more
core   +2 more sources

On the nature of the Milky Way satellites [PDF]

Monthly Notices of the Royal Astronomical Society, 2010
18 pages, 16 figures.
Li Yang-Shyang, De Lucia Gabriella, Helmi Amina   +2 more
openaire   +4 more sources