Results 221 to 230 of about 28,520 (293)

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: The hidden circumgalactic medium. [PDF]

Open Res Eur
Lee M, Schimek A, Cicone C, Andreani P, Popping G, Sommovigo L, Appleton PN, Bischetti M, Cantalupo S, Chen CC, Dannerbauer H, De Breuck C, Di Mascolo L, Emonts BHC, Hatziminaoglou E, Pensabene A, Rizzo F, Rybak M, Shen S, Lundgren A, Booth M, Klaassen P, Mroczkowski T, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone T, Saintonge A, Smith M, Thelen AE, Wedemeyer S.   +31 more
europepmc   +1 more source

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

Small, EarlyView.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu, Jazmina L. Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C. Domínguez Cadena, Shuhang Li, Zeinab G. Khalil, Waleed M. Hussein, Jingwen Wang, Jolynn Kiong, Xuehan Lu, Jiahui Zhang, Miao Lu, Wenbin Huang, Wei Yang Kong, Ummey Jannatun Nahar, Prashamsa Koirala, Zhong Guo, Patricia Walden, Antje Blumenthal, Jakob Begun, Kirill Alexandrov, Istvan Toth, Rachel J. Stephenson, Mariusz Skwarczynski   +25 more
wiley   +1 more source

Primordial black holes and their gravitational-wave signatures. [PDF]

Living Rev Relativ
Bagui E, Clesse S, De Luca V, Ezquiaga JM, Franciolini G, García-Bellido J, Joana C, Kumar Jain R, Kuroyanagi S, Musco I, Papanikolaou T, Raccanelli A, Renaux-Petel S, Riotto A, Ruiz Morales E, Scalisi M, Sergijenko O, Ünal C, Vennin V, Wands D, LISA Cosmology Working Group.   +20 more
europepmc   +1 more source

Spatiotemporal Co‐Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi‐Modal In Vivo Study

Small, EarlyView.
A spatiotemporal co‐delivery microneedle system (MN‐Mg) is developed for spinal cord injury repair. By generating hydrogen gas and magnesium ions in situ, this dual‐engine platform effectively scavenges ROS and modulates microglial polarization via the MAPK/AP‐1 signaling axis.
Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo, Yiwei Zhu, Yu Feng, Kun Xi, Liang Chen   +13 more
wiley   +1 more source

Unexpected major geomagnetic storm caused by faint eruption of a solar trans-equatorial flux rope. [PDF]

Nat Commun
Teng W, Su Y, Ji H, Zhang Q.
europepmc   +1 more source

Systemic Governance From Below: Story Telling to Empower Access to the Commons Through Mapping and Modelling: A Mixed Methods Approach

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Access to forests, farming land and the Citarum river is limited in Tarumajaya; furthermore, many do not own their own housing and are dependent on the public and private landowners in the area. The region of Tarumajaya faces significant challenges in access to crucial resources such as forests, farming land and the Citarum river, leading to a
Rudolf Wirawan, Janet Judy McIntyre‐Mills, R. Riswanda R. Riswanda, Ida Widianingsih, Indra Gunawan   +4 more
wiley   +1 more source

‘Knowledge, attitudes and practices’ survey of Austrian veterinarians' antibiotic use in clinical practice

Veterinary Record, EarlyView.
Abstract Background Antimicrobial resistance (AMR) is a critical global health issue, with antimicrobial use (AMU) in veterinary medicine playing a relevant role in its emergence. This study aimed to evaluate the knowledge, attitudes and practices of Austrian veterinarians regarding AMU and AMR.
Clair L. Firth, Patricia Mayer, Annemarie Käsbohrer, Tanja Tripolt, Klemens Fuchs   +4 more
wiley   +1 more source

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

VIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa, Laura Palumbo, Martina La Rosa, Antonella Girgenti, Fabio Salvatore Palumbo, Pasquale Picone, Francesco Lopresti, Domenico Nuzzo, Vincenzo La Carruba   +8 more
wiley   +1 more source

A detailed analysis of the Czernik 38 cluster and its associated tidal tail, utilizing Gaia DR3 and 2MASS. [PDF]

Sci Rep
Ahmed NM.
europepmc   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source