Results 111 to 120 of about 5,633,642 (286)

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Observational Constraints of Radial Migration in the Galactic Disk Driven by the Slowing Bar

The Astrophysical Journal Letters
Radial migration is an important dynamical effect that has reshaped the Galactic disk, but its origin has yet to be elucidated. In this work, we present evidence that resonant dragging by the corotation of a decelerating bar could be the main driver of ...
HanYuan Zhang, Vasily Belokurov, N. Wyn Evans, Jason L. Sanders, Yuxi(Lucy) Lu, Chengye Cao, GyuChul Myeong, Adam M. Dillamore, Sarah G. Kane, Zhao-Yu Li   +9 more
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

The Age-dependent Vertical Actions of Young Stars in the Galaxy

The Astrophysical Journal
Stars in the Galactic disk are born on cold, nearly circular orbits with small vertical excursions. After their birth, their orbits evolve, driven by small- or large-scale perturbations in the Galactic disk’s gravitational potential.
D. N. Garzon, Neige Frankel, Eleonora Zari, Maosheng Xiang, Hans-Walter Rix   +4 more
doaj   +1 more source

Substructure Depletion in the Milky Way Halo by the Disk

, 2019
We employ numerical simulations and simple analytical estimates to argue that dark matter substructures orbiting in the inner regions of the Galaxy can be efficiently destroyed by disk shocking, a dynamical process known to affect globular star clusters.
Keres, Dusan, Hernquist, Lars, Springel, Volker, D'Onghia, Elena   +3 more
core   +1 more source

Influence of Fat Oil Binding Capacity on Shelf‐Life and Consumer Acceptance of a Chocolate‐Based Model System

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT In chocolate‐coated products, oil migration can lead to chocolate softening and discoloration, filling hardening, and reduced consumer acceptance. This study examined three fats (soy‐, palm‐, and palm‐kernel (PK) based), crystallized under different conditions (cooling rate and high intensity ultrasound (HIU)) with differing oil binding ...
Audrey Lidgard, Farnaz Maleky, Silvana Martini   +2 more
wiley   +1 more source

Computational Role in Thermal Engineering and Chemical Analytics During the Rotating Disk of Generalized Williamson Viscosity and Thermal Conductivity

Advanced Physics Research, EarlyView.
The schematic diagram shows the flow configuration of the model. The swirling flow of shear‐thinning materials is significantly investigated under the influence of mixed convection. In addition, heat and mass transfer flow characteristics along with gyrotactic microorganisms is also investigated. ABSTRACT Thermal conductivity, temperature gradient, and
Latif Ahmad, Hafiz Ur Rahman, Umair Khan, Syed Modassir Hussain   +3 more
wiley   +1 more source

The Age–Thickness Relation as a Tracer of the Merger History of Disk Galaxies

The Astrophysical Journal
In the hierarchical framework of galaxy formation, disk galaxies are shaped by a sequence of mergers and interactions, yet reconstructing this history from observations remains challenging.
Lekshmi Thulasidharan, Elena D’Onghia, Robert Benjamin, Ronald Drimmel, Eloisa Poggio   +4 more
doaj   +1 more source

The Milky Way has no thick disk

, 2011
Different stellar sub-populations of the Milky Way's stellar disk are known to have different vertical scale heights, their thickness increasing with age. Using SEGUE spectroscopic survey data, we have recently shown that mono-abundance sub-populations, defined in the [α/Fe]-[Fe/H] space, are well described by single exponential spatial-density ...
Bovy, Jo, Rix, Hans-Walter, Hogg, David W.   +2 more
openaire   +2 more sources