Results 201 to 210 of about 44,865 (311)

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi   +10 more
wiley   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan   +7 more
wiley   +1 more source

EVENT HORIZON TELESCOPE EVIDENCE FOR ALIGNMENT OF THE BLACK HOLE IN THE CENTER OF THE MILKY WAY WITH THE INNER STELLAR DISK [PDF]

open access: bronze, 2014
Dimitrios Psaltis   +5 more
openalex   +1 more source

The Quality of Clarity: Lessons from the Sixty‐Year Struggle to Maintain the Purity of Lake Taupō

open access: yesKōtuitui: New Zealand Journal of Social Sciences Online, Volume 21, Issue 2, June 2026.
Sixty years of effort to protect the exceptionally clear water of Lake Taupō, the largest lake in Aotearoa New Zealand, show how environmental memory can help manage a cultural and natural resource. I describe how water clarity and quality in this lake have been protected, through managing soil erosion and phosphorus flows during the 1960s–1980s, and ...
Jonathan West
wiley   +1 more source

Development and Optimization of a Nanophytosomes‐Based Thermogel as a Topical Anti‐Psoriatic for Increased Solubility and Bioavailability

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Schematic illustration of the development, optimization, and therapeutic evaluation of the Leucas aspera phytosome‐based thermogel for topical antipsoriatic therapy, highlighting its enhanced solubility, skin deposition, and in vivo efficacy in an imiquimod‐induced psoriasis model. Created with BioRender.com.
Ananda Kumar Chettupalli   +2 more
wiley   +1 more source

First submillimeter lights from Dome A: Tracing the carbon cycle in the feedback of massive stars. [PDF]

open access: yesSci Adv
Gong Y   +40 more
europepmc   +1 more source

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