Results 41 to 50 of about 3,911 (275)

ORIGIN AND EVOLUTION OF THE ABUNDANCE GRADIENT ALONG THE MILKY WAY DISK

open access: yes, 2009
Based on a simple model of the chemical evolution of the Milky Way disk, we investigate the disk oxygen abundance gradient and its time evolution. Two star formation rates (SFRs) are considered, one is the classical Kennicutt-Schmidt law (Psi = 0.25 ...
Chang, R. X.   +3 more
core   +1 more source

Jeans Equations in the Milky Way disk using Gaia DR3

open access: yes, 2023
<p>Determining the circular velocity curve of a galaxy is a powerful tool for studying its overall properties. One can fit a potential and determine the dark matter distribution and density and the virial mass of the system.<br> One way of ...
Koop, Orlin   +2 more
core   +1 more source

Disentangling Stellar Age Estimates from Galactic Chemodynamical Evolution

open access: yesThe Astrophysical Journal, 2023
Stellar ages are key for determining the formation history of the Milky Way, but are difficult to measure precisely. Furthermore, methods that use chemical abundances to infer ages may entangle the intrinsic evolution of stars with the chemodynamical ...
Jeff Shen   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

GASTRO Library. II. Exploring Chemical Bimodalities in Disk Galaxies with GSE-like Mergers and Massive Star-forming Clumps

open access: yesThe Astrophysical Journal
We use several smoothed particle hydrodynamics+ N -body models as part of the GASTRO library to study the role of high-density star-forming clumpy regions and a single merger on the formation of the α -rich and α -poor populations in the disk galaxies ...
João A. S. Amarante   +12 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

open access: yesAdvanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk   +7 more
wiley   +1 more source

The Three-phase Evolution of the Milky Way

open access: yesThe Astrophysical Journal
We illustrate the formation and evolution of the Milky Way over cosmic time, utilizing a sample of 10 million red giant stars with full chemodynamical information, including metallicities and α -abundances from low-resolution Gaia XP spectra.
Vedant Chandra   +8 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia   +17 more
wiley   +1 more source

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