Results 41 to 50 of about 1,984 (304)

Milky Way dynamics in light of Gaia

New Astronomy Reviews
The Gaia mission has triggered major developments in the field of Galactic dynamics in recent years, which we discuss in this review. The structure and kinematics of all Galactic components - disc, bar/bulge and halo - are now mapped in great detail not only in the Solar neighbourhood, but across a large part of the Milky Way. The dramatic improvements
Jason A.S. Hunt, Eugene Vasiliev
openaire   +2 more sources

GAS DYNAMICS IN THE MILKY WAY: A LOW PATTERN SPEED MODEL [PDF]

The Astrophysical Journal, 2016
ABSTRACT We present gas flow models for the Milky Way based on high-resolution grid-based hydrodynamical simulations. The basic galactic potential we use is from an N-body model constrained by the density of red clump giants in the Galactic bulge.
Zhi Li, Ortwin Gerhard, Juntai Shen, Matthieu Portail, Christopher Wegg   +4 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Stream Fanning and Bifurcations: Observable Signatures of Resonances in Stellar Stream Morphology

The Astrophysical Journal, 2023
Recent observations have revealed a trove of unexpected morphological features in many of the Milky Way’s stellar streams. Explanations for such features include time-dependent deformations of the Galactic gravitational potential, local disruptions ...
Tomer D. Yavetz, Kathryn V. Johnston, Sarah Pearson, Adrian M. Price-Whelan, Chris Hamilton   +4 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Minimum-entropy Constraints on Galactic Potentials

The Astrophysical Journal
A tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva, Monica Valluri, Eugene Vasiliev, Kohei Hattori, Walter de Siqueira Pedra, Kathryne J. Daniel   +5 more
doaj   +1 more source

Chemo-dynamical signatures in simulated Milky Way-like galaxies

Proceedings of the International Astronomical Union, 2017
AbstractWe have investigated the chemo-dynamical evolution of a Milky Way-like disk galaxy, AqC4, produced by a cosmological simulation integrating a sub-resolution ISM model. We evidence a global inside-out and upside-down disk evolution, that is consistent with a scenario where the “thin disk” stars are formed from the accreted gas close to the ...
Alessandro Spagna, Anna Curir, Marco Giammaria, Mario G. Lattanzi, Giuseppe Murante, Paola Re Fiorentin   +5 more
openaire   +2 more sources

Dark Matter distribution in the Milky Way: microlensing and dynamical constraints [PDF]

Journal of Cosmology and Astroparticle Physics, 2011
We show that current microlensing and dynamical observations of the Galaxy permit to set interesting constraints on the Dark Matter local density and profile slope towards the galactic centre. Assuming state-of-the-art models for the distribution of baryons in the Galaxy, we find that the most commonly discussed Dark Matter profiles (viz. Navarro-Frenk-
Iocco F., Pato M., Bertone G., Jetzer P.
openaire   +4 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source