Results 51 to 60 of about 45,998 (281)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

The Milky Way's nuclear star cluster and massive black hole

, 2014
Because of its nearness to Earth, the centre of the Milky Way is the only galaxy nucleus in which we can study the characteristics, distribution, kinematics, and dynamics of the stars on milli-parsec scales.
Schödel, Rainer
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Galactic Forces Rule the Dynamics of Milky Way Dwarf Galaxies [PDF]

The Astrophysical Journal, 2018
Abstract Dwarf galaxies populating the Galactic halo are assumed to host the largest fractions of dark matter, as calculated from their velocity dispersions. Their major axes are preferentially aligned with the Vast Polar Structure (VPOS) that is perpendicular to the Galactic disk, and we find their velocity gradients aligned as well ...
Hammer, Francois, Yang, Yanbin, Arenou, Frédéric, Babusiaux, Carine, Wang, Jianling, Puech, Mathieu, Flores, Hector   +6 more
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Phase Spiral’s Origin and Evolution: Indications from Its Varying Properties across the Milky Way Disk

The Astrophysical Journal
The phase spiral is a perturbation to the vertical phase-space distribution of stars in the Milky Way disk. We study the phase spiral’s properties and how they vary with spatial position, in order to constrain its origin and evolution, as well as ...
Axel Widmark, Kiyan Tavangar, Joshua Kalish, Kathryn V. Johnston, Jason A. S. Hunt   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source