Results 61 to 70 of about 179,998 (300)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Additional Evidence for the Existence of a Primordial Disk System
The Astrophysical JournalThe origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu +9 more
doaj +1 more source
Gas dynamics and large-scale morphology of the Milky Way galaxy [PDF]
Monthly Notices of the Royal Astronomical Society, 1999 We present a new model for the gas dynamics in the galactic disk inside the Sun's orbit. Quasi-equilibrium flow solutions are determined in the gravitational potential of the deprojected COBE NIR bar and disk, complemented by a central cusp and, in some models, an outer halo.
Englmaier, Peter, Gerhard, Ortwin
openaire +2 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The Astrophysical JournalThe phase spiral is a perturbation to the vertical phase-space distribution of stars in the Milky Way disk. We study the phase spiral’s properties and how they vary with spatial position, in order to constrain its origin and evolution, as well as ...
Axel Widmark +4 more
doaj +1 more source
Nearly coeval intermediate-age Milky Way star clusters at very different dynamics evolutionary stages [PDF]
Monthly notices of the Royal Astronomical Society, 2019 We report astrophysical properties of 12 Milky Way open clusters located beyond a 2 kpc circle around the Sun by using deep optical photometry. We estimated their age and metallicities on the basis of a maximum likelihood approach using astrometric ...
A. Piatti, M. Angelo, W. S. Dias
semanticscholar +1 more source
GAS DYNAMICS IN THE MILKY WAY: A LOW PATTERN SPEED MODEL [PDF]
The Astrophysical Journal, 2016 ABSTRACT We present gas flow models for the Milky Way based on high-resolution grid-based hydrodynamical simulations. The basic galactic potential we use is from an N-body model constrained by the density of red clump giants in the Galactic bulge.
Zhi Li +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Spiral Structure Properties, Dynamics, and Evolution in Milky Way–mass Galaxy Simulations
Astrophysical JournalThe structure of spiral galaxies is essential to understanding the dynamics and evolution of disk galaxies; however, the precise nature of spiral arms remains uncertain.
J. Quinn +10 more
semanticscholar +1 more source