Results 71 to 80 of about 179,998 (300)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

On the dynamics of tidal streams in the Milky Way galaxy

, 2010
We present a brief history of Galactic astrophysics, and explain the origin of halo substructure in the Galaxy. We motivate our study of tidal streams by highlighting the tight constraints that analysis of the trajectories of tidal streams can place on the form of the Galactic potential.
Eyre, A, Eyre, Andy
openaire   +3 more sources

Minimum-entropy Constraints on Galactic Potentials

The Astrophysical Journal
A tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva, Monica Valluri, Eugene Vasiliev, Kohei Hattori, Walter de Siqueira Pedra, Kathryne J. Daniel   +5 more
doaj   +1 more source

Probing Turbulence, Gravity, Supernovae, and Magnetic Field Effects with the 6D Kinematics of Young Stars in Milky Way Star-forming Regions [PDF]

Astrophysical Journal
The dynamics of star-forming gas can be affected by many physical processes, such as turbulence, gravity, supernova explosions, and magnetic fields. In this paper, we investigate several nearby star-forming regions (Orion, Upper Sco, Taurus, and Perseus)
Benjamin N. Velguth, Yuan Li, Trung Ha, Yue Hu, M. Kounkel, Siyao Xu, R. Gutermuth, Hui Li, Martin D. Weinberg   +8 more
semanticscholar   +1 more source

Dynamical evidence of the age-metallicity relation in the Milky Way disk [PDF]

Astronomy & Astrophysics, 2006
We studied the relationship between the average stellar abundance of several elements and the orbital evolution of stars in the neighbourhood of the Sun, using both observational data for 325 late-type dwarfs in a volume-complete sample and simulations of the orbital diffusion.
Rocha-Pinto, H. J., Rangel, R. H. O., de Mello, G. F. Porto, Braganca, G. A., Maciel, W. J.   +4 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dark Matter distribution in the Milky Way: microlensing and dynamical constraints [PDF]

Journal of Cosmology and Astroparticle Physics, 2011
We show that current microlensing and dynamical observations of the Galaxy permit to set interesting constraints on the Dark Matter local density and profile slope towards the galactic centre. Assuming state-of-the-art models for the distribution of baryons in the Galaxy, we find that the most commonly discussed Dark Matter profiles (viz. Navarro-Frenk-
Iocco F., Pato M., Bertone G., Jetzer P.
openaire   +4 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

An Inward-moving and Asymmetric Velocity Wave Detected in LAMOST-Gaia

The Astrophysical Journal Letters
The phase space, as coded by kinematic parameters and chemical abundances, is crucial for understanding the formation of the Galactic disk. Using red giant stars from the Galactic thin disk with [Fe/H] > − 0.8 and low- α ratios identified in LAMOST-Gaia,
Yuqin Chen, Gang Zhao, Wenbo Wu, Zixi Guo, Haopeng Zhang, Zhuohan Li   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source