Results 151 to 160 of about 75,563 (322)

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way

The Astronomical Journal
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution ...
Jack T. Warfield, Joel C. Zinn, Jessica Schonhut-Stasik, James W. Johnson, Marc H. Pinsonneault, Jennifer A. Johnson, Dennis Stello, Rachael L. Beaton, Yvonne Elsworth, Rafael A. García, Savita Mathur, Benoît Mosser, Aldo Serenelli, Jamie Tayar   +13 more
doaj   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source

A Perspective on the Milky Way Bulge Bar as Seen from the Neutron-capture Elements Cerium and Neodymium with APOGEE

The Astrophysical Journal
This study probes the chemical abundances of the neutron-capture elements cerium and neodymium in the inner Milky Way from an analysis of a sample of ∼2000 stars in the Galactic bulge bar spatially contained within ∣ X _Gal ∣ < 5 kpc, ∣ Y _Gal ∣ < 3.5 ...
J. V. Sales-Silva, K. Cunha, V. V. Smith, S. Daflon, D. Souto, R. Guerço, A. Queiroz, C. Chiappini, C. R. Hayes, T. Masseron, Sten Hasselquist, D. Horta, N. Prantzos, M. Zoccali, C. Allende Prieto, B. Barbuy, R. Beaton, D. Bizyaev, J. G. Fernández-Trincado, P. M. Frinchaboy, J. A. Holtzman, J. A. Johnson, Henrik Jönsson, S. R. Majewski, D. Minniti, D. L. Nidever, R. P. Schiavon, M. Schultheis, J. Sobeck, G. S. Stringfellow, G. Zasowski   +30 more
doaj   +1 more source

Analysis of enrichment histories for elements and two modes of star formation during the early evolution of Milky Way [PDF]

, 2014
Shimako Yamada, Takuma Suda, Yutaka Komiya, Wako Aoki, Masayuki Y. Fujimoto   +4 more
openalex   +1 more source

An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide

Advanced Materials, EarlyView.
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon, Charles T. Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister, Jessica R. Kramer   +5 more
wiley   +1 more source

Insights into the Galactic Bulge Chemodynamical Properties from Gaia Data Release 3

The Astrophysical Journal
We explore the chemodynamical properties of the Galaxy in the azimuthal velocity V _ϕ and metallicity [Fe/H] space using red giant stars from Gaia Data Release 3.
Xiaojie Liao, Zhao-Yu Li, Iulia Simion, Juntai Shen, Robert Grand, Francesca Fragkoudi, Federico Marinacci   +6 more
doaj   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

The evolution of stellar metallicity gradients of the Milky Way disk from LSS-GAC main sequence turn-off stars: a two-phase disk formation history? [PDF]

, 2015
Maosheng Xiang, Xiaowei Liu, Haibo Yuan, Yang Huang, Chun Wang, Juanjuan Ren, Bingqiu Chen, Ning-Chen Sun, Huawei Zhang, Zhi-Ying Huo, A. Rebassa–Mansergas   +10 more
openalex   +1 more source