Results 151 to 160 of about 76,255 (323)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way

The Astronomical Journal
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution ...
Jack T. Warfield, Joel C. Zinn, Jessica Schonhut-Stasik, James W. Johnson, Marc H. Pinsonneault, Jennifer A. Johnson, Dennis Stello, Rachael L. Beaton, Yvonne Elsworth, Rafael A. García, Savita Mathur, Benoît Mosser, Aldo Serenelli, Jamie Tayar   +13 more
doaj   +1 more source

FORMATION AND EVOLUTION OF THE DISK SYSTEM OF THE MILKY WAY: [α/Fe] RATIOS AND KINEMATICS OF THE SEGUE G-DWARF SAMPLE [PDF]

, 2011
Young‐Sun Lee, Timothy C. Beers, Deokkeun An, Željko Ivezić, Andreas Just, Constance M. Rockosi, Heather L. Morrison, Jennifer A. Johnson, Ralph Schönrich, Jonathan Bird, Brian Yanny, Paul Harding, Helio J. Rocha-Pinto, Young‐Sun Lee, Timothy C. Beers, Deokkeun An, Željko Ivezić, Andreas Just, Constance M. Rockosi, Heather L. Morrison, Jennifer A. Johnson, Ralph Schönrich, Jonathan Bird, Brian Yanny, Paul Harding, Helio J. Rocha-Pinto   +25 more
openalex   +1 more source

Atomic Hydrogen in the Milky Way: A Stepping Stone in the Evolution of Galaxies [PDF]

, 2023
N. M. McClure‐Griffiths, Snežana Stanimirović, Daniel R. Rybarczyk   +2 more
openalex   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

A Perspective on the Milky Way Bulge Bar as Seen from the Neutron-capture Elements Cerium and Neodymium with APOGEE

The Astrophysical Journal
This study probes the chemical abundances of the neutron-capture elements cerium and neodymium in the inner Milky Way from an analysis of a sample of ∼2000 stars in the Galactic bulge bar spatially contained within ∣ X _Gal ∣ < 5 kpc, ∣ Y _Gal ∣ < 3.5 ...
J. V. Sales-Silva, K. Cunha, V. V. Smith, S. Daflon, D. Souto, R. Guerço, A. Queiroz, C. Chiappini, C. R. Hayes, T. Masseron, Sten Hasselquist, D. Horta, N. Prantzos, M. Zoccali, C. Allende Prieto, B. Barbuy, R. Beaton, D. Bizyaev, J. G. Fernández-Trincado, P. M. Frinchaboy, J. A. Holtzman, J. A. Johnson, Henrik Jönsson, S. R. Majewski, D. Minniti, D. L. Nidever, R. P. Schiavon, M. Schultheis, J. Sobeck, G. S. Stringfellow, G. Zasowski   +30 more
doaj   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

Insights into the Galactic Bulge Chemodynamical Properties from Gaia Data Release 3

The Astrophysical Journal
We explore the chemodynamical properties of the Galaxy in the azimuthal velocity V _ϕ and metallicity [Fe/H] space using red giant stars from Gaia Data Release 3.
Xiaojie Liao, Zhao-Yu Li, Iulia Simion, Juntai Shen, Robert Grand, Francesca Fragkoudi, Federico Marinacci   +6 more
doaj   +1 more source

Chemical Evolution in the Milky Way: Rotation-based Ages for APOGEE-Kepler Cool Dwarf Stars [PDF]

, 2020
Zachary R. Claytor, Jennifer L. van Saders, Ângela R G Santos, Rafael A. García, Savita Mathur, Jamie Tayar, Marc H. Pinsonneault, Matthew Shetrone, Zachary R. Claytor, Jennifer L. van Saders, Ângela R G Santos, Rafael A. García, Savita Mathur, Jamie Tayar, Marc H. Pinsonneault, Matthew Shetrone   +15 more
openalex   +1 more source