Results 161 to 170 of about 77,216 (325)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

A Measurement of the Assembly of Milky Way Analogs at Redshifts 0.5 < z < 2 with Resolved Stellar Mass and Star Formation Rate Profiles

The Astrophysical Journal
The resolved mass assembly of Milky Way–mass galaxies has been previously studied in simulations, the local Universe, and at higher redshifts using infrared (IR) light profiles.
Vivian Yun Yan Tan, Adam Muzzin, Danilo Marchesini, Visal Sok, Ghassan T. E. Sarrouh, Z. Cemile Marsan   +5 more
doaj   +1 more source

"Fermi" bubbles are bursting from our galaxy. Their origins remain a mystery. [PDF]

Proc Natl Acad Sci U S A, 2023
Mann A.
europepmc   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

The Warm–Hot Disk–Halo Interface below the Perseus Spiral Arm

The Astrophysical Journal
The Milky Way’s disk–halo interface mediates energy and mass exchange between the interstellar thin disk and the halo. In the first detailed study of the Perseus arm’s disk–halo interface, we combine Hubble Space Telescope/Space Telescope Imaging ...
Ananya G. Tuli, Nicolas Lehner, J. Christopher Howk, Todd M. Tripp, Andrew J. Fox, Frances H. Cashman   +5 more
doaj   +1 more source

The Milky Way and the evolution of disk galaxies

, 2002
We present a phenomenological approach to the study of disk galaxy evolution, based on i) a detailed modelling of the Milky Way (used as a prototype disk galaxy) and ii) an extension of the model to other disks through some simple scaling relations, obtained in the framework of Cold Dark matter models.
openaire   +2 more sources

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Effects of secular growth and mergers on the evolution of metallicity gradients and azimuthal variations in a Milky Way-like galaxy [PDF]

Florent Renaud, Bridget Ratcliffe, Ivan Minchev, Misha Haywood, P. Di Matteo, Oscar Agertz, Alessandro B. Romeo   +6 more
openalex   +1 more source

A comprehensive model for the formation and evolution of the faintest Milky Way dwarf satellites [PDF]

, 2023
Niusha Ahvazi, Andrew Benson, Laura V. Sales, Ethan O. Nadler, Sachi Weerasooriya, Xiaolong Du, Mia Sauda Bovill   +6 more
openalex   +1 more source