Results 101 to 110 of about 267,615 (357)

SEGUE-2: Old Milky Way Stars Near and Far

Astrophysical Journal Supplement Series, 2022
The Sloan Extension for Galactic Understanding and Exploration 2 (SEGUE-2) obtained 128,288 low-resolution spectra (R ∼ 1800) of 118,958 unique stars in the first year of the Sloan Digital Sky Survey III (2008–2009).
C. Rockosi, Young Sun Lee, H. Morrison, B. Yanny, Jennifer A. Johnson, S. Lucatello, J. Sobeck, T. Beers, C. Allende Prieto, D. An, D. Bizyaev, M. Blanton, L. Casagrande, D. Eisenstein, A. Gould, J. Gunn, P. Harding, I. Ivans, H. Jacobson, W. Janesh, G. Knapp, J. Kollmeier, S. Lépine, M. López-Corredoira, Zhibo Ma, H. Newberg, K. Pan, J. Prchlik, Conor Sayers, K. Schlesinger, J. Simmerer, D. Weinberg   +31 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way

The Astrophysical Journal
The search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin, Alessandro Spagna, Mario G. Lattanzi, Michele Cignoni, Sara Vitali   +4 more
doaj   +1 more source

OBSERVATIONAL EVIDENCE OF DYNAMIC STAR FORMATION RATE IN MILKY WAY GIANT MOLECULAR CLOUDS [PDF]

, 2016
Star formation on galactic scales is known to be a slow process, but whether it is slow on smaller scales is uncertain. We cross-correlate 5469 giant molecular clouds (GMCs) from a new all-sky catalog with 256 star-forming complexes (SFCs) to build a ...
Eve J. Lee, M. Miville-Deschênes, N. Murray   +2 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars

The Astrophysical Journal Supplement Series
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu   +3 more
doaj   +1 more source

Theoretical Models of the Galactic Bulge

, 2015
Near infrared images from the COBE satellite presented the first clear evidence that our Milky Way galaxy contains a boxy shaped bulge. Recent years have witnessed a gradual paradigm shift in the formation and evolution of the Galactic bulge. Bulges were
Li, Zhao-Yu, Shen, Juntai
core   +1 more source

The formation of the Milky Way halo and its dwarf satellites; a NLTE-1D abundance analysis. II. Early chemical enrichment [PDF]

, 2017
We present the non-local thermodynamic equilibrium (NLTE) abundances of up to 10 chemical species in a sample of 59 very metal-poor (VMP, -4 < [Fe/H] < -2) stars in seven dwarf spheroidal galaxies (dSphs) and in the Milky Way (MW) halo.
L. Mashonkina, P. Jablonka, P. Jablonka, T. Sitnova, Y. Pakhomov, P. North   +5 more
semanticscholar   +1 more source