Results 101 to 110 of about 482,942 (363)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

The Parallax and 3D Kinematics of Water Masers in the Massive Star-forming Region G034.43+0.24

The Astrophysical Journal, 2023
We report a measurement of the trigonometric parallax of 22 GHz water masers in the massive star-forming region G034.43+0.24 as part of the Bar and Spiral Structure Legacy Survey using the Very Long Baseline Array.
Xiaofeng Mai, Bo Zhang, M. J. Reid, L. Moscadelli, Shuangjing Xu, Yan Sun, Jingdong Zhang, Wen Chen, Shiming Wen, Qiuyi Luo, Karl M. Menten, Xingwu Zheng, Andreas Brunthaler, Ye Xu, Guangli Wang   +14 more
doaj   +1 more source

A low pre-infall mass for the Carina dwarf galaxy from disequilibrium modelling [PDF]

Nature Communications 6, Article number: 7599, (2015), 2015
Dark matter only simulations of galaxy formation predict many more subhalos around a Milky Way like galaxy than the number of observed satellites. Proposed solutions require the satellites to inhabit dark matter halos with masses between one to ten billion solar masses at the time they fell into the Milky Way.
arxiv   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way

The Astrophysical Journal
The search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin, Alessandro Spagna, Mario G. Lattanzi, Michele Cignoni, Sara Vitali   +4 more
doaj   +1 more source

The origin of the Milky Way globular clusters [PDF]

, 2016
We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters, and the environmental evolution through cosmic times in the form of tidal tensors.
arxiv   +1 more source

The formation of the Milky Way halo and its dwarf satellites; a NLTE-1D abundance analysis. II. Early chemical enrichment [PDF]

, 2017
We present the non-local thermodynamic equilibrium (NLTE) abundances of up to 10 chemical species in a sample of 59 very metal-poor (VMP, -4 < [Fe/H] < -2) stars in seven dwarf spheroidal galaxies (dSphs) and in the Milky Way (MW) halo.
L. Mashonkina, P. Jablonka, P. Jablonka, T. Sitnova, Y. Pakhomov, P. North   +5 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source