Results 81 to 90 of about 9,204,018 (295)

A Model for the Formation of the Milky Way [PDF]

, 2017
A new chemodynamical model for the formation and evolution of a Milky Way type galaxy is introduced. In this scenario, the galaxy forms inside a slowly growing dark matter halo in a ΛCDM cosmology. In contrast to the simple merger and collapse scenarios,
Samland, Markus
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Gas accretion onto the Milky Way

, 2017
The Milky Way is surrounded by large amounts of gaseous matter that are slowly being accreted over cosmic timescales to support star formation in the disk.
Richter, Philipp (Prof. Dr.)
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Divergent Evolution of Radial Metallicity Gradients in the Thin and Thick Disks of the Milky Way

The Astrophysical Journal Letters
Using 200,388 red clump stars from LAMOST and APOGEE, we investigate the radial metallicity gradients of the Galactic disk as a function of vertical height and stellar age. The thin disk displays a pronounced negative radial metallicity gradient near the
Weixiang Sun, Gaohuan Long, Hui Li, Han Shen, Shu Wang, Xiaodian Chen, Biwei Jiang, Xiaowei Liu, Di Li   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Milky Way Tomography with Subaru Hyper Suprime-Cam: Possible Implications for the Past Orbit of the Large Magellanic Cloud

The Astrophysical Journal Letters
We report the discovery of diffuse stellar substructure in the outer halo of the Milky Way (MW) toward Boötes, unveiled by deep imaging data of the Subaru/Hyper Suprime-Cam.
Yoshihisa Suzuki, Masashi Chiba, Rosemary F. G. Wyse   +2 more
doaj   +1 more source

Bar Formation in Milky Way type Galaxies

Open Astronomy, 2016
Many barred galaxies, possibly including the Milky Way, have cusps in their centers. There is a widespread belief, however, that the usual bar instability, which occurs in bulgeless galaxy models, is impossible for cuspy models because of the presence of
Polyachenko E. V., Berczik P., Just A.
doaj   +1 more source

Milky Way of Words

, 2016
No Full ...
Frank, Jane
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source