Results 61 to 70 of about 9,204,018 (295)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way
The Astrophysical JournalThe search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin +4 more
doaj +1 more source
Very Metal-poor Stars in the Solar Vicinity: Kinematics and Abundance Analysis
The Astrophysical Journal, 2023 Very metal-poor stars contain crucial information on the Milky Way’s infancy. In our previous study we derived a mean age of ∼13.7 Gyr for a sample of these stars in the Sun’s vicinity.
Anastasiia Plotnikova +3 more
doaj +1 more source
Chemical Abundances and Milky Way Formation [PDF]
, 2006 to be published in the proceedings of the ESO/Arcetri-workshop on "Chemical Abundances and Mixing in Stars", 13.-17. Sep. 2004, Castiglione della Pescaia, Italy, L. Pasquini, S. Randich (eds.)
Gilmore, Gerry, Wyse, Rosemary F. G.
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A 3D Chemodynamical Census of Inner-Galaxy Metal-poor Giants to [Fe/H] ∼ −3.5
The Astrophysical Journal LettersThe earliest assembly of the Milky Way remains poorly understood, yet the spatial, chemical, and kinematic properties of its most metal-poor stars provide a unique fossil record of its proto-Galaxy phase.
Shenglan Sun +10 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the Formation of Planets in the Milky Way’s Thick Disk
The Astrophysical JournalAbstract Exoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk. One key difference between the two stellar populations is the time at which they emerged: thick-disk stars are the likely product
Tim Hallatt, Eve J. Lee
openaire +3 more sources
Star Formation in the Milky Way: The Infrared View [PDF]
, 2013 12 pages, 9 figures. To apper in "Cosmic-ray induced phenomenology in star-forming environments: Proceedings of the 2nd Session of the Sant Cugat Forum of Astrophysics" (April 16-19, 2012), Olaf Reimer and Diego F. Torres (eds.)
openaire +2 more sources
A NEW FORMATION SCENARIO FOR THE MILKY WAY CLUSTER NGC 2419 [PDF]
The Astrophysical Journal, 2011 35 pages, 13 figures, accepted for publication in ...
Bruens, R. C., Kroupa, P.
openaire +2 more sources