Results 51 to 60 of about 8,310 (262)

Star Formation in the Milky Way: The Infrared View [PDF]

, 2013
12 pages, 9 figures. To apper in "Cosmic-ray induced phenomenology in star-forming environments: Proceedings of the 2nd Session of the Sant Cugat Forum of Astrophysics" (April 16-19, 2012), Olaf Reimer and Diego F. Torres (eds.)
openaire   +2 more sources

Chemical Abundances and Milky Way Formation [PDF]

, 2006
to be published in the proceedings of the ESO/Arcetri-workshop on "Chemical Abundances and Mixing in Stars", 13.-17. Sep. 2004, Castiglione della Pescaia, Italy, L. Pasquini, S. Randich (eds.)
Gilmore, Gerry, Wyse, Rosemary F. G.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the Formation of Planets in the Milky Way’s Thick Disk

The Astrophysical Journal
Abstract Exoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk. One key difference between the two stellar populations is the time at which they emerged: thick-disk stars are the likely product
Tim Hallatt, Eve J. Lee
openaire   +3 more sources

THE STAR FORMATION HISTORY OF THE MILKY WAY'S NUCLEAR STAR CLUSTER [PDF]

The Astrophysical Journal, 2011
ApJ accepted, 17 figures, 3 ...
Pfuhl, O., Fritz, T., Zilka, M., Maness, H., Eisenhauer, F., Genzel, R., Gillessen, S., Ott, T., Dodds-Eden, K., Sternberg, A.   +9 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A NEW FORMATION SCENARIO FOR THE MILKY WAY CLUSTER NGC 2419 [PDF]

The Astrophysical Journal, 2011
35 pages, 13 figures, accepted for publication in ...
Bruens, R. C., Kroupa, P.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

HR-GO. II. Chemical Abundances of Low-E Retrograde Dynamically Tagged Groups: Revealing Thamnos as a Very Metal-poor Substructure

The Astrophysical Journal
Milky Way halo substructures identified in dynamical space are known to suffer from contamination from the Milky Way in situ stars, which makes their accreted origins uncertain. We present detailed chemical abundances of 35 stars belonging to two sets of
Renjing Xie, Zhen Yuan, Haining Li, Tadafumi Matsuno, Nicolas F. Martin, Ruizhi Zhang, Zhiqiang Yan, Federico Sestito, Guillaume F. Thomas, Projjwal Banerjee, Ruizheng Jiang, Linda Lombardo, David S. Aguado, Kohei Hattori, Gang Zhao   +14 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source