Results 51 to 60 of about 9,540,019 (262)

HR-GO. II. Chemical Abundances of Low-E Retrograde Dynamically Tagged Groups: Revealing Thamnos as a Very Metal-poor Substructure

The Astrophysical Journal
Milky Way halo substructures identified in dynamical space are known to suffer from contamination from the Milky Way in situ stars, which makes their accreted origins uncertain. We present detailed chemical abundances of 35 stars belonging to two sets of
Renjing Xie, Zhen Yuan, Haining Li, Tadafumi Matsuno, Nicolas F. Martin, Ruizhi Zhang, Zhiqiang Yan, Federico Sestito, Guillaume F. Thomas, Projjwal Banerjee, Ruizheng Jiang, Linda Lombardo, David S. Aguado, Kohei Hattori, Gang Zhao   +14 more
doaj   +1 more source

A Model for the Formation of the Milky Way [PDF]

, 2017
A new chemodynamical model for the formation and evolution of a Milky Way type galaxy is introduced. In this scenario, the galaxy forms inside a slowly growing dark matter halo in a ΛCDM cosmology. In contrast to the simple merger and collapse scenarios,
Samland, Markus
core  

The Milky Way Nuclear Star Cluster

, 2011
In the center of the Milky Way, as well as in many other galaxies, a compact star cluster around a very massive black hole is observed. One of the possible explanations for the formation of such Nuclear Star Clusters is based on the "merging" of globular
Pfuhl, O., Zilka, M., O. Pfuhl, A. Mastrobuono-battisti, F. Antonini, ANTONINI, FABIO, A. Sternberg, Sternberg, A., T. K. Fritz, R. Genzel, S. Gillessen, Gillessen, S., MASTROBUONO BATTISTI, ALESSANDRA, F. Eisenhauer, Eisenhauer, F., T. Ott, Maness, H., Ott, T., H. Maness, M. Zilka, CAPUZZO DOLCETTA, Roberto Angelo, Dodds-Eden, K., Genzel, R., Fritz, T., K. Dodds-Eden, R. Capuzzo-dolcetta   +25 more
core   +1 more source

Are the Milky Way and Andromeda unusual? A comparison with Milky Way and Andromeda analogues

, 2020
Our Milky Way provides a unique test case for galaxy evolution models because of our privileged position within the Milky Way's disc. This position also complicates comparisons between the Milky Way and external galaxies, due to our inability to observe ...
Boardman, N., Newman, J. A., Masters, K., Zasowski, G., Mackereth, T., Fielder, C., Krishnarao, D., Brinkmann, J., Drory, N., Stringfellow, G. S., Bershady, M., Andrews, B., Lane, R. R., Boardman, Nicholas, Zasowski, Gail, Newman, Jeffrey A., Andrews, Brett, Masters, Karen   +17 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars

The Astrophysical Journal Supplement Series
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Orbital Anisotropy Profile of the Gaia-Sausage/Enceladus Accretion Remnant

The Astrophysical Journal
The Gaia - Sausage/Enceladus (GS/E) accretion remnant is one of the most important stellar populations in the Milky Way halo. Recent simulation-based work has suggested that the anisotropy profiles of remnants like GS/E decline towards the center and may
James M. M. Lane, Jo Bovy
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source