Results 31 to 40 of about 9,540,019 (262)
The Mass of the Milky Way Galaxy [PDF]
, 2023 On the Basis of tabular values of the gravitational constant. The calculated mass of the nucleus of the milky way galaxy. The numerical value of the gravitational constant is determined by the mass of the nucleus of the milky way galaxy.
Shavkyatovich, Yanbikov Vildan
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ORIGIN AND EVOLUTION OF THE ABUNDANCE GRADIENT ALONG THE MILKY WAY DISK
, 2009 Based on a simple model of the chemical evolution of the Milky Way disk, we investigate the disk oxygen abundance gradient and its time evolution. Two star formation rates (SFRs) are considered, one is the classical Kennicutt-Schmidt law (Psi = 0.25 ...
Chang, R. X. +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys
The Astrophysical Journal Supplement SeriesPhotometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong +17 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Additional Evidence for the Existence of a Primordial Disk System
The Astrophysical JournalThe origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu +9 more
doaj +1 more source
A Tilt in the Dark Matter Halo of the Galaxy
The Astrophysical Journal, 2022 Recent observations of the stellar halo have uncovered the debris of an ancient merger, Gaia–Sausage–Enceladus (GSE), estimated to have occurred ≳8 Gyr ago.
Jiwon Jesse Han +11 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source