Results 71 to 80 of about 9,204,018 (295)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

HR-GO. II. Chemical Abundances of Low-E Retrograde Dynamically Tagged Groups: Revealing Thamnos as a Very Metal-poor Substructure

The Astrophysical Journal
Milky Way halo substructures identified in dynamical space are known to suffer from contamination from the Milky Way in situ stars, which makes their accreted origins uncertain. We present detailed chemical abundances of 35 stars belonging to two sets of
Renjing Xie, Zhen Yuan, Haining Li, Tadafumi Matsuno, Nicolas F. Martin, Ruizhi Zhang, Zhiqiang Yan, Federico Sestito, Guillaume F. Thomas, Projjwal Banerjee, Ruizheng Jiang, Linda Lombardo, David S. Aguado, Kohei Hattori, Gang Zhao   +14 more
doaj   +1 more source

The simulation of molecular clouds formation in the Milky Way [PDF]

Monthly Notices of the Royal Astronomical Society, 2012
10 pages, 8 ...
Khoperskov, S. A., Vasiliev, E. O., Sobolev, A. M., Khoperskov, A. V.   +3 more
openaire   +2 more sources

Stellar abundances in clusters: High-resolution, multi-object spectroscopy of globular & open clusters in the Milky Way [PDF]

, 2015
Talk on high-resolution, multi-object spectroscopy of globular & open clusters in the Milky ...
BRAGAGLIA, Angela
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars

The Astrophysical Journal Supplement Series
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu   +3 more
doaj   +1 more source

The Formation of the Milky Way Nuclear Cluster

, 2011
4 pages, 4 figures, To appear in "Advances in Computational Astrophysics: methods, tools and outcomes", ASP Conference Series, R. Capuzzo-Dolcetta, M. Limongi and A.
A. Mastrobuono Battisti, CAPUZZO DOLCETTA, Roberto Angelo   +1 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Orbital Anisotropy Profile of the Gaia-Sausage/Enceladus Accretion Remnant

The Astrophysical Journal
The Gaia - Sausage/Enceladus (GS/E) accretion remnant is one of the most important stellar populations in the Milky Way halo. Recent simulation-based work has suggested that the anisotropy profiles of remnants like GS/E decline towards the center and may
James M. M. Lane, Jo Bovy
doaj   +1 more source