Results 91 to 100 of about 9,540,019 (262)

Rising from the Ashes: A Metallicity-dependent Star Formation Gap Splits the Milky Way’s α Sequences

The Astrophysical Journal
The elemental abundance distribution of stars encodes the history of the gas-phase abundance in the Milky Way. Without a large, unbiased sample of highly precise stellar ages, the exact timing and nature of this history must be inferred from the ...
Angus Beane
doaj   +1 more source

Tracing the formation of the Milky Way through ultra metal-poor stars [PDF]

, 2019
We use Gaia DR2 astrometric and photometric data, published radial velocities and MESA models to infer distances, orbits, surface gravities, and effective temperatures for all ultra metal-poor stars ([Fe/H] 11 Gyr) and that they are expected to belong ...
Starkenburg, Else, Martin, N., Fouesneau, M., Longeard, Nicolas, Carlberg, R., Navarro, Julio, Ibata, Rodrigo, González Hernández, J., Longeard, N., Navarro, Julio F., Aguado, D., Carlberg, Raymond, Venn, K., Ibata, R., Martin, Nicolas, Navarro, J., Tolstoy, Eline, Tolstoy, E., Arentsen, A., Jablonka, P., Fouesneau, Morgan, Jablonka, Pascale, Aguado, David, Venn, Kim A., Martin, Nicolas F., Aguado, David S., Carlberg, Raymond G., Starkenburg, E., Arentsen, Anke, Gonzalez Hernandez, Jonay I., Sestito, Federico, Sestito, F., González hernández, Jonay, Venn, Kim, Martin, Nicolas F, Aguado, David S, Venn, Kim A, Carlberg, Raymond G, González Hernández, Jonay I, Navarro, Julio F   +39 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

True Pair-instability Supernova Descendant: Implications for the First Stars’ Mass Distribution

The Astrophysical Journal Letters
The initial mass function (IMF) of the first Population III (Pop III) stars remains a persistent mystery. Their predicted massive nature implies the existence of stars exploding as pair-instability supernovae (PISNe), but no observational evidence had ...
Ioanna Koutsouridou, Stefania Salvadori, Ása Skúladóttir   +2 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Precise Asteroseismic Ages for the Helmi Streams

The Astrophysical Journal
The Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay, Marc Hon, J. M. Joel Ong, Rafael A. García, Dinil B. Palakkatharappil, Jie Yu, Tanda Li, Tomás Ruiz-Lara, Amina Helmi   +8 more
doaj   +1 more source

Stellar abundances in clusters: High-resolution, multi-object spectroscopy of globular & open clusters in the Milky Way [PDF]

, 2015
Talk on high-resolution, multi-object spectroscopy of globular & open clusters in the Milky ...
BRAGAGLIA, Angela
core  

Milky Way reionisation with GAMESH

, 2018
Talk done at DAVID Meeting 2014 on MIlky Way ...
Luca Graziani, Luca Graziani (6005609)
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source