Results 91 to 100 of about 8,310 (262)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Precise Asteroseismic Ages for the Helmi Streams
The Astrophysical JournalThe Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay +8 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
Sources of formation of HII in the milky way galaxy [PDF]
, 2020 Kaynakça (s. 67-68) var.
openaire +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Milky Way’s Metal-poor Stars Display Chemical Transition near the Solar Radius
The Astrophysical Journal LettersThe metal-poor stars of a galaxy offer insights into that galaxy’s early formation processes and accretion history. Here, we investigate whether the metal-poor stars of our Milky Way Galaxy exhibit any characteristic trends in Galactocentric distance ...
Khyati Malhan
doaj +1 more source
A Compact Spin‐Coated Graphene UWB Antenna for Breast Tumor Detection
Advanced Engineering Materials, EarlyView.A compact, spin‐coated graphene ultra‐wideband patch antenna designed for breast tumor detection, capable of distinguishing between malignant and benign tumors. This innovative antenna can serve as an effective initial screening tool, particularly in resource‐limited settings such as rural areas, where access to advanced medical equipment like MRI and ...
Raja Rashidul Hasan +9 more
wiley +1 more source
The Star Formation History of the Milky Way
, 2000 10pp, to appear in Disk galaxies and galaxy disks, eds J G Funes and E M corsini ASP Conf ser in ...
openaire +2 more sources
Advanced Engineering Materials, EarlyView.This study reports the development of antibacterial ceramic scaffolds derived from natural bovine bone. The bones were processed through sequential boiling and hydrogen peroxide treatment to remove organic matter, producing porous, mineral‐rich scaffolds.
Mohamad Hassan Taherian +6 more
wiley +1 more source
Disk Assembly of the Milky Way Suggested from the Time-resolved Chemical Abundance
The Astrophysical JournalBoth simulations and observations suggest that the disk assembly of galaxies is governed by the interplay between coplanar gas inflow, ex-planar gas outflow, and in situ star formation on the disk, known as the leaky accretion disk.
Enci Wang +3 more
doaj +1 more source